ArticleThe Journal of physiology2011
Spinal direct current stimulation modulates the activity of gracile nucleus and primary somatosensory cortex in anaesthetized rats.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does trans-spinal direct current stimulation modulate the Hoffmann reflexes of healthy individuals? A systematic review and meta-analysisc.Spinal cord · 2018Pooled it
- Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex.Scientific reports · 2020Trial
- Transcutaneous spinal direct current stimulation induces lasting fatigue resistance and enhances explosive vertical jump performance.PloS one · 2017Trial
- Does trans-spinal direct current stimulation alter phrenic motoneurons and respiratory neuromechanical outputs in humans? A double-blind, sham-controlled, randomized, crossover study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Article
- Exercise-Activated mPFC Tri-Synaptic Pathway Ameliorates Depression-Like Behaviors in Mouse.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- From brain to spinal cord: neuromodulation by direct current stimulation and its promising effects as a treatment option for restless legs syndrome.Frontiers in neurology · 2024Review
- Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective.Biomedicines · 2023Review
- Non-Invasive Transcutaneous Spinal DC Stimulation as a Neurorehabilitation ALS Therapy in Awake G93A Mice: The First Step to Clinical Translation.Bioengineering (Basel, Switzerland) · 2022Article
- Anodal transcutaneous DC stimulation enhances learning of dynamic balance control during walking in humans with spinal cord injury.Experimental brain research · 2022Article
- Trans-Spinal Direct Current Stimulation Targets CaFrontiers in neuroscience · 2022Article
- The effect of cathodal transspinal direct current stimulation on tibialis anterior stretch reflex components in humans.Experimental brain research · 2022Article
- Exploration of the Supraspinal Hypotheses about Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation: A Systematic Review.Journal of clinical medicine · 2021Review
- Effects of Transcutaneous Spinal Direct Current Stimulation (tsDCS) in Patients With Chronic Pain: A Clinical and Neurophysiological Study.Frontiers in neurology · 2021Article
- Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans.Physiological reports · 2020Article
- Regional Hyperexcitability and Chronic Neuropathic Pain Following Spinal Cord Injury.Cellular and molecular neurobiology · 2020Review
- Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes.Journal of neuroengineering and rehabilitation · 2019Review
- Repeated cathodal transspinal pulse and direct current stimulation modulate cortical and corticospinal excitability differently in healthy humans.Experimental brain research · 2019Article
- Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future.Anesthesiology · 2019Review
- Transspinal Direct Current Stimulation Produces Persistent Plasticity in Human Motor Pathways.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Afferent somatosensory activity from the spinal cord has a profound impact on the activity of the brain. Here we investigated the effects of spinal stimulation using direct current, delivered at the thoracic level, on the spontaneous activity and on the somatosensory evoked potentials of the gracile nucleus, which is the main entry point for hindpaw somatosensory signals reaching the brain from the dorsal columns, and of the primary somatosensory cortex in anaesthetized rats. Anodal spinal direct current stimulation (sDCS) increased the spontaneous activity and decreased the amplitude of evoked responses in the gracile nucleus, whereas cathodal sDCS produced the opposite effects. At the level of the primary somatosensory cortex, the changes in spontaneous activity induced by sDCS were consistent with the effects observed in the gracile nucleus, but the changes in cortical evoked responses were more variable and state dependent. Therefore, sDCS can modulate in a polarity-specific manner the supraspinal activity of the somatosensory system, offering a versatile bottom-up neuromodulation technique that could potentially be useful in a number of clinical applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.