Trial reportBMC neurology2011
Troponin elevation in acute ischemic stroke (TRELAS)--protocol of a prospective observational trial.
Trial report in BMC neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01263964 (Troponin Elevation in Acute Ischemic Stroke), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Troponin Elevation in Acute Ischemic Stroke (TRELAS) - a Prospective Study on the Frequency and Correlation to Coronary Artery Disease and to Stroke Localisation
Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Admission Uric Acid, Troponin, and C-Reactive Protein Levels and In-Hospital Mortality in Acute Stroke Patients.International journal of general medicine · 2026Article
- Coronary angiography in acute ischemic stroke patients: frequency and determinants of pathological findings in a multicenter cohort study.Journal of neurology · 2022Article
- Review
- Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction.Journal of cachexia, sarcopenia and muscle · 2019Article
- Cardiac Magnetic Resonance Imaging in Patients with Acute Ischemic Stroke and Elevated Troponin: A TRoponin ELevation in Acute Ischemic Stroke (TRELAS) Sub-Study.Cerebrovascular diseases extra · 2019Observational
- High-sensitivity cardiac troponin T and severity of cerebral white matter lesions in patients with acute ischemic stroke.Journal of neurology · 2019Article
- [Troponin elevation in ischemic stroke patients].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- [Acute coronary syndrome in acute stroke].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- The association of CHA2DS2-VASc score and blood biomarkers with ischemic stroke outcomes: the Belgrade stroke study.PloS one · 2014Article
- Atrial fibrillation, elevated troponin, ischemic stroke and adverse outcomes: understanding the connection.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Elevated troponin level with negative outcome was found in ischemic stroke.Cardiovascular psychiatry and neurology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLevels of the cardiac muscle regulatory protein troponin T (cTnT) are frequently elevated in patients with acute ischemic stroke and elevated cTnT predicts poor outcome and mortality. The pathomechanism of troponin release may relate to co-morbid coronary artery disease and myocardial ischemia or, alternatively, to neurogenic cardiac damage due to autonomic activation after acute ischemic stroke. Therefore, there is uncertainty about how acute ischemic stroke patients with increased cTnT levels should be managed regarding diagnostic and therapeutic workup. METHODS/
designThe primary objective of the prospective observational trial TRELAS (TRoponin ELevation in Acute ischemic Stroke) is to investigate the frequency and underlying pathomechanism of cTnT elevation in acute ischemic stroke patients in order to give guidance for clinical practice. All consecutive patients with acute ischemic stroke admitted within 72 hours after symptom onset to the Department of Neurology at the Campus Benjamin Franklin of the University Hospital Charité will be screened for cTnT elevations (i.e. ≥ 0.05 μg/l) on admission and again on the following day. Patients with increased cTnT will undergo coronary angiography within 72 hours. Diagnostic findings of coronary angiograms will be compared with age- and gender-matched patients presenting with Non-ST-Elevation myocardial infarction to the Department of Cardiology. The primary endpoint of the study will be the occurrence of culprit lesions in the coronary angiogram indicating underlying co-morbid obstructive coronary artery disease. Secondary endpoints will be the localization of stroke in the cerebral imaging and left ventriculographic findings of wall motion abnormalities suggestive of stroke-induced global cardiac dysfunction. DISCUSSION: TRELAS will prospectively determine the frequency and possible etiology of troponin elevation in a large cohort of ischemic stroke patients. The findings are expected to contribute to clarify pathophysiologic concepts of co-morbid cardiac damage in ischemic stroke patients and also to provide a basis for clinical recommendations for cardiac workup of such patients.
trial registrationclinicaltrials.gov NCT01263964.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.