ArticleBiological chemistry2011
Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis.
Article in Biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Evolutionary degeneration of septins into pseudoGTPases: impacts on a hetero-oligomeric assembly interface.Frontiers in cell and developmental biology · 2023Article
- Chaperone requirements for de novo folding ofMolecular biology of the cell · 2022Article
- Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis.Molecular biology of the cell · 2018Article
- Dividing the Archaeal Way: The Ancient Cdv Cell-Division Machinery.Frontiers in microbiology · 2018Review
- Cytokinesis in Metazoa and Fungi.Cold Spring Harbor perspectives in biology · 2017Review
- High CO2 Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation.Molecular and cellular biology · 2015Article
- Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast.Molecular biology of the cell · 2015Article
- Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions.Genes & development · 2015Article
- ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo.PLoS genetics · 2015Article
- ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases.International journal of molecular sciences · 2014Review
- An inside-out origin for the eukaryotic cell.BMC biology · 2014Article
- The Arabidopsis Endosomal Sorting Complex Required for Transport III Regulates Internal Vesicle Formation of the Prevacuolar Compartment and Is Required for Plant Development.Plant physiology · 2014Article
- Article
- Article
- Septin phosphorylation and coiled-coil domains function in cell and septin ring morphology in the filamentous fungus Ashbya gossypii.Eukaryotic cell · 2013Article
- Membrane fission reactions of the mammalian ESCRT pathway.Annual review of biochemistry · 2013Review
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Review
- Septin ring size scaling and dynamics require the coiled-coil region of Shs1p.Molecular biology of the cell · 2012Article
- The ESCRT machinery: from the plasma membrane to endosomes and back again.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Membrane trafficking via targeted exocytosis to the Saccharomyces cerevisiae bud neck provides new membrane and membrane-associated factors that are critical for cytokinesis. It remains unknown whether yeast plasma membrane abscission, the final step of cytokinesis, occurs spontaneously following extensive vesicle fusion, as in plant cells, or requires dedicated membrane fission machinery, as in cultured mammalian cells. Components of the endosomal sorting complexes required for transport (ESCRT) pathway, or close relatives thereof, appear to participate in cytokinetic abscission in various cell types, but roles in cell division had not been documented in budding yeast, where ESCRTs were first characterized. By contrast, the septin family of filament-forming cytoskeletal proteins were first identified by their requirement for yeast cell division. We show here that mutations in ESCRT-encoding genes exacerbate the cytokinesis defects of cla4Δ or elm1Δ mutants, in which septin assembly is perturbed at an early stage in cell division, and alleviate phenotypes of cells carrying temperature-sensitive alleles of a septin-encoding gene, CDC10. Elevated chitin synthase II (Chs2) levels coupled with aberrant morphogenesis and chitin deposition in elm1Δ cells carrying ESCRT mutations suggest that ESCRTs normally enhance the efficiency of cell division by promoting timely endocytic turnover of key cytokinetic enzymes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.