ReviewBiochemistry2011
Pericyclic reactions catalyzed by chorismate-utilizing enzymes.
Review in Biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- (Reverse) Evolution of a Promiscuous Isochorismate Pyruvate Lyase into an Efficient Chorismate Mutase.Biochemistry · 2025Article
- Mechanistic basis for the emergence of EPS1 as a catalyst in salicylic acid biosynthesis of Brassicaceae.Nature communications · 2024Article
- The influence of model building schemes and molecular dynamics sampling on QM-cluster models: the chorismate mutase case study.Physical chemistry chemical physics : PCCP · 2024Article
- What Drives Chorismate Mutase to Top Performance? Insights from a CombinedBiochemistry · 2023Article
- The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery.Natural product reports · 2019Review
- Plants fight fungi using kiwellin proteins.Nature · 2019Article
- Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study.Current opinion in structural biology · 2018Review
- Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions.Biochemistry · 2018Review
- Unraveling the Structure and Mechanism of the MST(ery) Enzymes.Trends in biochemical sciences · 2018Review
- An Open and Shut Case: The Interaction of Magnesium with MST Enzymes.Journal of the American Chemical Society · 2016Article
- Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.Bioorganic & medicinal chemistry · 2014Article
- Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes.Nature chemical biology · 2014Article
- Redesign of MST enzymes to target lyase activity instead promotes mutase and dehydratase activities.Archives of biochemistry and biophysics · 2013Article
- Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited.Archives of biochemistry and biophysics · 2013Article
- Exploration of swapping enzymatic function between two proteins: a simulation study of chorismate mutase and isochorismate pyruvate lyase.Protein science : a publication of the Protein Society · 2013Article
- Current developments and challenges in the search for a naturally selected Diels-Alderase.Current opinion in chemical biology · 2012Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
One of the fundamental questions of enzymology is how catalytic power is derived. This review focuses on recent developments in the structure--function relationships of chorismate-utilizing enzymes involved in siderophore biosynthesis to provide insight into the biocatalysis of pericyclic reactions. Specifically, salicylate synthesis by the two-enzyme pathway in Pseudomonas aeruginosa is examined. The isochorismate-pyruvate lyase is discussed in the context of its homologues, the chorismate mutases, and the isochorismate synthase is compared to its homologues in the MST family (menaquinone, siderophore, or tryptophan biosynthesis) of enzymes. The tentative conclusion is that the activities observed cannot be reconciled by inspection of the active site participants alone. Instead, individual activities must arise from unique dynamic properties of each enzyme that are tuned to promote specific chemistries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.