Evidence map›Paper›PMID 21823599›Full record

ArticleNano letters2011

Cancer-targeted optical imaging with fluorescent zinc oxide nanowires.

Hao Hong, Jian Shi, Yunan Yang, Yin Zhang, Jonathan W Engle, Robert J Nickles, Xudong Wang, Weibo Cai

Abstract read
In one paragraph

Article in Nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. PLGA-Based Composites for Various Biomedical Applications.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Magnetic and Highly Luminescent Heterostructures of GdNanomaterials (Basel, Switzerland) · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Recent Advances in Zinc Oxide Nanostructures with Antimicrobial Activities.International journal of molecular sciences · 2020
    Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao HongDepartment of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Jian Shi
Yunan Yang
Yin Zhang
Jonathan W Engle
Robert J Nickles
Xudong Wang
Weibo Cai

Funding

INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
NCI NIH HHS 5 T32 CA009206-32NCI NIH HHS T32 CA009206NCRR NIH HHS UL1 RR025011
6 · The paper itself

Abstract

Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin α(v)β(3) on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.

Indexed as

Biocompatible MaterialsCell Line, TumorHumansIntegrin alphaVbeta3Metal NanoparticlesMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionMicroscopy, FluorescenceModels, ChemicalNanowiresNeoplasmsOligopeptidesOptics and PhotonicsSolubilityZinc Oxidearginyl-glycyl-aspartic acidBiocompatible MaterialsIntegrin alphaVbeta3OligopeptidesZinc Oxide

Identifiers

PMID21823599
PMCPMC3173586

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.