ReviewWiley interdisciplinary reviews. RNA
RITS-connecting transcription, RNA interference, and heterochromatin assembly in fission yeast.
Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- The Role of microRNA in the Regulation of Differentiation and the Functionality of Osteoblasts, Osteoclasts, and Their Precursors in Osteoporosis.Non-coding RNA · 2025Review
- Non-coding RNA-mediated epigenetic alterations in Grave's ophthalmopathy: A scoping systematic review.Non-coding RNA research · 2023Article
- Subtelomeric Chromatin in the Fission YeastMicroorganisms · 2021Review
- RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.RNA biology · 2019Review
- Visualizing nuclear RNAi activity in single living human cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Molecular mechanisms of Dicer: endonuclease and enzymatic activity.The Biochemical journal · 2017Review
- SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.Molecular cell · 2016Article
- Regulation of mammalian transcription and splicing by Nuclear RNAi.Nucleic acids research · 2016Review
- Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation.EMBO reports · 2016Article
- Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.Scientific reports · 2015Article
- Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.World journal of virology · 2015Review
- Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.Cell cycle (Georgetown, Tex.) · 2015Article
- Natural genetic variation impacts expression levels of coding, non-coding, and antisense transcripts in fission yeast.Molecular systems biology · 2014Article
- The MicroRNA Biology of the Mammalian Nucleus.Molecular therapy. Nucleic acids · 2014Article
- Article
- Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer.Open biology · 2013Review
- Review
- Non-coding RNAs: multi-tasking molecules in the cell.International journal of molecular sciences · 2013Review
- Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In recent years, a bevy of evidence has been unearthed indicating that 'silent' heterochromatin is not as transcriptionally inert as once thought. In the unicellular yeast Schizosaccharomyces pombe, the processing of transcripts derived from centromeric repeats into homologous short interfering RNA (siRNA) is essential for the formation of centromeric heterochromatin. Deletion of genes required for siRNA biogenesis showed that core components of the canonical RNA interference (RNAi) pathway are essential for centromeric heterochromatin assembly as well as for centromere function. Subsequent purification of the RNA-induced initiation of transcriptional gene silencing (RITS) complex provided the critical link between siRNAs and heterochromatin assembly, with RITS acting as a physical bridge between noncoding RNA scaffolds and chromatin. Here, we review current understanding of how RITS promotes heterochromatin formation and how it participates in transcription-coupled silencing. WIREs RNA 2011 2 632-646 DOI: 10.1002/wrna.80 For further resources related to this article, please visit the WIREs website.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.