ReviewMolecular reproduction and development
The multiple hats of Vasa: its functions in the germline and in cell cycle progression.
Review in Molecular reproduction and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Collagen processing is essential for germ cell identity.Biology open · 2025Article
- Article
- Characteristics of theGenes · 2024Article
- Silencing of the Vasa gene by RNA Interference Affects Embryonic Development and Reproductive Output in the Sea Louse Caligus rogercresseyi.Marine biotechnology (New York, N.Y.) · 2023Article
- Article
- The essential role of Dnmt1 ineLife · 2021Article
- The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging.Frontiers in cell and developmental biology · 2021Review
- Integrin-alpha-6+ Candidate stem cells are responsible for whole body regeneration in the invertebrate chordate Botrylloides diegensis.Nature communications · 2020Article
- DEAD-Box Helicase 4 (Ddx4)International journal of molecular sciences · 2020Article
- Molecular approaches underlying the oogenic cycle of the scleractinian coral, Acropora tenuis.Scientific reports · 2020Article
- Gene Function Rather than Reproductive Mode Drives the Evolution of RNA Helicases in Sexual and Apomictic Boechera.Genome biology and evolution · 2020Article
- Contrasting patterns of molecular evolution in metazoan germ line genes.BMC evolutionary biology · 2019Article
- Germ cell line during the seasonal sexual rest of clams: finding niches of cells for gonad renewal.Histochemistry and cell biology · 2018Article
- Ovarian Cancer Stem Cells: Unraveling a Germline Connection.Stem cells and development · 2017Article
- An unregulated regulator: Vasa expression in the development of somatic cells and in tumorigenesis.Developmental biology · 2016Review
- The diversity of nanos expression in echinoderm embryos supports different mechanisms in germ cell specification.Evolution & development · 2016Article
- Methods to study maternal regulation of germ cell specification in zebrafish.Methods in cell biology · 2016Article
- Developmental expression of "germline"- and "sex determination"-related genes in the ctenophore Mnemiopsis leidyi.EvoDevo · 2016Article
- Identification of germ cell-specific VASA and IFITM3 proteins in human ovarian endometriosis.Journal of ovarian research · 2015Article
- Preliminary characterization and expression of Vasa-like gene in Schistosoma japonicum.Parasitology research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vasa, an ATP-dependent RNA helicase, is broadly conserved among various organisms from cnidarians to mammals. It has a rich history of utility as a germline marker, and is believed to function as a positive translational regulator in the determination and maintenance of germline cells. Studies in non-model organisms, however, revealed that Vasa is also present in somatic cells of many tissues. In many cases these cells are multipotent, are non-germline associated, and give rise to a variety of different tissue types. Recent work now also demonstrates that Vasa functions in the regulation of the cell cycle. Here, we discuss this newly described function of Vasa in mitotic and meiotic cell cycles, and we address the conundrum created within these observations, that is, that most cells are mitotically independent of Vasa, yet when Vasa is present in a cell, it appears to be essential for cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.