ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2011
Zn- and Cu-thioneins: a functional classification for metallothioneins?
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Divergent metallothionein strategies underlie copper tolerance in Saccharomyces species relevant to winemaking.Applied microbiology and biotechnology · 2026Article
- Experimental recombining of repetitive motifs leads to large functional metallothioneins and demonstrates their modular evolvability potential.Protein science : a publication of the Protein Society · 2025Article
- Mechanistic insights into uptake, transfer and exchange of metal ions by the three-metal clusters of a metalloprotein.Protein science : a publication of the Protein Society · 2024Article
- Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Evolution of Cd2+ and Cu+ binding in Helix pomatia metallothioneins.Metallomics : integrated biometal science · 2023Article
- A de novo evolved domain improves the cadmium detoxification capacity of limpet metallothioneins.Scientific reports · 2023Article
- The Modular Architecture of Metallothioneins Facilitates Domain Rearrangements and Contributes to Their Evolvability in Metal-Accumulating Mollusks.International journal of molecular sciences · 2022Article
- Comparative cisplatin reactivity towards human Zn7-metallothionein-2 and MTF-1 zinc fingers: potential implications in anticancer drug resistance.Metallomics : integrated biometal science · 2022Article
- Study on metal binding capacity of the freshwater crab Sinopotamon henanense's recombinant copper specific binding metallothionein expressed in Escherichia coli.Ecotoxicology (London, England) · 2022Article
- Metal-Specificity Divergence between Metallothioneins ofInternational journal of molecular sciences · 2021Article
- Article
- Tunicates Illuminate the Enigmatic Evolution of Chordate Metallothioneins by Gene Gains and Losses, Independent Modular Expansions, and Functional Convergences.Molecular biology and evolution · 2021Article
- The Enigmatic Metallothioneins: A Case of Upward-Looking Research.International journal of molecular sciences · 2021Article
- Metal Binding Ability of Small Peptides Containing Cysteine Residues.ChemistryOpen · 2021Article
- Article
- Modular Evolution and Population Variability ofFrontiers in cell and developmental biology · 2021Article
- Two Unconventional Metallothioneins in the Apple SnailInternational journal of molecular sciences · 2020Article
- Interaction between Polyphenolic Antioxidants andBiomolecules · 2020Article
- The evolution of insect metallothioneins.Proceedings. Biological sciences · 2020Article
- Mechanisms of Copper Tolerance, Accumulation, and Detoxification in the Marine MacroalgaPlants (Basel, Switzerland) · 2020Review
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3 authors.
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Abstract
This report intends to provide the reader with a deeper insight in the chemical, and extensively biological, characteristics of the metallothionein (MT) system. We have devoted nearly 20 years to the study of MTs and this has allowed us to form what we believe is a more complete picture of this peculiar family of metalloproteins. At the beginning of the 1990s, the landscape of this field was quite different from the overall picture we have now. Many researchers have contributed to the readjustment of this part of scientific knowledge. In our case, we implemented a unified method for obtaining MTs, for characterizing their metal-binding features, and for applying a unified research rationale. All this has helped to enlarge the initial picture that was mainly dominated by mammalian MT1/MT2 and yeast Cup1, by introducing approximately 20 new MTs. It has also allowed some characteristics to be clarified and examined in more detail, such as the cooperativity or the coexistence of multiple species in the metal-substitution reactions, the availability of Ag(I) or Cd(II) for use as respective probes for the Cu(I) and Zn(II) binding sites, the participation of chloride or sulfide ligands in the metal coordination spheres, and the feasibility of using in vitro data as representative of in vivo scenarios. Overall, the results yield enough data to consider new criteria for a proposal of classification of MTs based on MT metal-binding features, which complements the previous classifications, and that can shed light on the still controversial physiological functions of this peculiar superfamily of metalloproteins.
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