ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2011
Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy.
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- Arsenic binding to human metallothionein-3.Chemical science · 2023Article
- Article
- Macrophage metallothioneins participate in the antileishmanial activity of antimonials.Frontiers in parasitology · 2023Article
- Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.PloS one · 2022Article
- Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain.Journal of neuroinflammation · 2021Article
- Metallic Orthodontic Materials Induce Gene Expression and Protein Synthesis of Metallothioneins.Materials (Basel, Switzerland) · 2021Article
- Mode of action-based risk assessment of genotoxic carcinogens.Archives of toxicology · 2020Review
- Exposure to Dichlorodiphenyldichloroethylene (DDE) and Metallothionein Levels in Rats Fed with Normocaloric or High-Fat Diet: A Review.International journal of molecular sciences · 2020Review
- Without 1α-hydroxylation, the gene expression profile of 25(OH)DScientific reports · 2018Article
- Early Suppression of Macrophage Gene Expression byFrontiers in microbiology · 2018Article
- ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth.Molecular cancer therapeutics · 2017Article
- Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Association of metallothionein expression and clinical response to cisplatin based chemotherapy in testicular germ cell tumors.Central European journal of urology · 2015Article
- Toxic metal proteomics: reaction of the mammalian zinc proteome with Cd²⁺.Journal of inorganic biochemistry · 2014Article
- Quantitation of human metallothionein isoforms: a family of small, highly conserved, cysteine-rich proteins.Molecular & cellular proteomics : MCP · 2014Article
- Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer.Clinical and experimental medicine · 2014Article
- Serum metallothioneins in childhood tumours-a potential prognostic marker.International journal of molecular sciences · 2013Article
- The role of metallothionein in oxidative stress.International journal of molecular sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present paper centers on mammalian metallothionein 1 and 2 in relationship to cell and tissue injury beginning with its reaction with Cd²⁺ and then considering its role in the toxicology and chemotherapy of both metals and non-metal electrophiles and oxidants. Intertwined is a consideration of MTs role in tumor cell Zn²⁺ metabolism. The paper updates and expands on our recent review by Petering et al. (Met Ions Life Sci 5:353-398, 2009).
Indexed as
Identifiers
21822976What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.