Evidence map›Paper›PMID 21822411›Full record

ArticleMarine drugs2011

A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus.

Charline Abed, Nathalie Legrave, Maeva Dufies, Guillaume Robert, Vincent Guérineau, Jean Vacelet, Patrick Auberger, Philippe Amade, Mohamed Mehiri

Abstract read
In one paragraph

Article in Marine drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Charline AbedChemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.
Nathalie LegraveChemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.
Maeva DufiesINSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France.
Guillaume RobertINSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France.
Vincent GuérineauCentre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Jean VaceletMarseille Oceanology Center, University of Aix-Marseille, CNRS UMR 6540 DIMAR, Endoume Marine Station, Batterie des Lions Street, 13007 Marseille, France.
Patrick AubergerINSERM UMR 895, Team 2, Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Saint-Antoine de Ginestiere Road, BP2 3194, 06204 Nice Cedex 3, France.
Philippe AmadeChemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.
Mohamed MehiriChemistry Laboratory of Biomolecules and Aroma, Nice Institute of Chemistry, UFR of Sciences, University of Nice-Sophia Antipolis, UMR-CNRS 6001, Parc Valrose, F-06108 Nice Cedex 02, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorDrug Screening Assays, AntitumorHumansHydroquinonesHydroxylationInhibitory Concentration 50K562 CellsMolecular StructureOceans and SeasPhytotherapyPlant ExtractsPoriferaAntineoplastic AgentsHydroquinonesPlant Extractsbioactivityhydroxylated polyprenylhydroquinonemarine natural productsSarcotragus spinosulussponges

Identifiers

PMID21822411
PMCPMC3148498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.