Evidence map›Paper›PMID 21822359›Full record

ArticleCommunications in nonlinear science & numerical simulation2011

Simulation of Drug Uptake in a Two Compartmental Fractional Model for a Biological System.

Ivo Petráš, Richard L Magin

Abstract read
In one paragraph

Article in Communications in nonlinear science & numerical simulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Fractional calculus in pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2018
    Article
  8. Article
  9. Article
  10. How to avoid unbounded drug accumulation with fractional pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2013
    Article
  11. Individualization of a pharmacokinetic model by fractional and nonlinear fit improvement.European journal of drug metabolism and pharmacokinetics · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ivo PetrášTechnical University of Košice, Faculty of BERG, Košice, B. Němcovej 3, Slovakia, ivo.petras@tuke.sk.
Richard L Magin

Funding

MR Monitoring of Engineered TissuesR01EB007537 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAGIN, RICHARD L · 2009 to 2012
$1.7M
NIBIB NIH HHS R01 EB007537
6 · The paper itself

Abstract

This paper presents a very effective numerical method for the solution of the two-compartmental pharmacokinetic model for oral drug administration. This model consists of a set of two fractional order differential equations which connect the two compartments. The first compartment represents the gut while the second compartment corresponds to the drug concentration in the target tissue. For ease of computation, the numerical solution is also created as a Matlab function.

Identifiers

PMID21822359
PMCPMC3150575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.