ArticleThe EMBO journal2011
Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- SUN-domain proteins of the malaria parasitemBio · 2025Article
- Regulator of Ribosome Synthesis 1 (RRS1) Stabilizes GRP78 and Promotes Breast Cancer Progression.Molecules (Basel, Switzerland) · 2024Article
- The secret life of chromatin tethers.FEBS letters · 2023Review
- A Yeast Mitotic Tale for the Nucleus and the Vacuoles to Embrace.International journal of molecular sciences · 2023Review
- Downregulated RRS1 inhibits invasion and metastasis of BT549 through RPL11‑c‑Myc‑SNAIL axis.International journal of oncology · 2022Article
- The Diverse Cellular Functions of Inner Nuclear Membrane Proteins.Cold Spring Harbor perspectives in biology · 2021Review
- The nucleolus as a polarized coaxial cable in which the rDNA axis is surrounded by dynamic subunit-specific phases.Current biology : CB · 2021Article
- Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases.Frontiers in cell and developmental biology · 2021Review
- Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage.PLoS genetics · 2019Article
- Systematic prediction of FFAT motifs across eukaryote proteomes identifies nucleolar and eisosome proteins with the predicted capacity to form bridges to the endoplasmic reticulum.Contact (Thousand Oaks (Ventura County, Calif.)) · 2019Article
- Comparative genomics of nuclear envelope proteins.BMC genomics · 2018Article
- Nuclear Envelope-Associated Chromosome Dynamics during Meiotic Prophase I.Frontiers in cell and developmental biology · 2017Review
- Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.Nucleus (Austin, Tex.) · 2016Article
- Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis.Nucleic acids research · 2015Article
- Making the LINC: SUN and KASH protein interactions.Biological chemistry · 2015Review
- The SUN protein Mps3 controls Ndc1 distribution and function on the nuclear membrane.The Journal of cell biology · 2014Article
- Functional organization and dynamics of the cell nucleus.Frontiers in plant science · 2014Review
- The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin.Chromosoma · 2013Review
- One identity or more for telomeres?Frontiers in oncology · 2013Article
- Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1.G3 (Bethesda, Md.) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two interacting ribosome biogenesis factors, Ebp2 and Rrs1, associate with Mps3, an essential inner nuclear membrane protein. Both are found in foci along the nuclear periphery, like Mps3, as well as in the nucleolus. Temperature-sensitive ebp2 and rrs1 mutations that compromise ribosome biogenesis displace the mutant proteins from the nuclear rim and lead to a distorted nuclear shape. Mps3 is known to contribute to the S-phase anchoring of telomeres through its interaction with the silent information regulator Sir4 and yKu. Intriguingly, we find that both Ebp2 and Rrs1 interact with the C-terminal domain of Sir4, and that conditional inactivation of either ebp2 or rrs1 interferes with both the clustering and silencing of yeast telomeres, while telomere tethering to the nuclear periphery remains intact. Importantly, expression of an Ebp2-Mps3 fusion protein in the ebp2 mutant suppresses the defect in telomere clustering, but not its defects in growth or ribosome biogenesis. Our results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomere tethering, by binding Sir4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.