ReviewCancer metastasis reviews1990
Cytogenetic abnormalities in cancer: with special emphasis on tumor heterogeneity.
Review in Cancer metastasis reviews, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Cancer Stem Cells: Emergent Nature of Tumor Emergency.Frontiers in genetics · 2018Article
- Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma.Journal of endocrinological investigation · 2000Article
- Amplification of the Y chromosome in three murine tumor cell lines transformed in vivo by different human prostate cancers.In vitro cellular & developmental biology. Animal · 1999Article
- Can cancer cells transform normal host cells into malignant cells?British journal of cancer · 1997Article
- Chromosome 1 in human colorectal tumors. Cytogenetic research on structural changes and their significance.Human genetics · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
There is a considerable amount of cytogenetic data available to support the statements that (1) cancer is a genetic disease; (2) most cancers are monoclonal in origin; (3) tumor cells are more genetically unstable than normal cells; (4) the genetic instability may be inherited, acquired, or both during the lifespan of the individual tumor; (5) tumor metastasis is a nonrandom, controlled process, and clonal in origin; (6) malignant tumors are genetically heterogeneous and contain multiple subpopulations that may differ in their biological properties; (7) some tumors might be difficult to treat successfully because of their resistant nature; and (8) tumor cells may acquire resistance because of gene amplification. For these reasons it is extremely important to study the biology of malignant tumor cells in order to determine their effective treatments and control this dreadful disease.
Indexed as
Identifiers
2182210What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.