Evidence map›Paper›PMID 21821789›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2011

Retrotransposons that maintain chromosome ends.

Mary-Lou Pardue, P G DeBaryshe

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 126 citations in OpenAlex.

  1. Determinants of dicentric chromosome breakage inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. The leaves fall, yet the tree endures.Cellular and molecular life sciences : CMLS · 2025
    Review
  5. A degenerate telomerase RNA directs telomeric DNA synthesis in lepidopteran insects.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Cells · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mary-Lou PardueDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. mlpardue@mit.edu
P G DeBaryshe
Massachusetts Institute of Technology · US

Funding

HET-A, A RETROPOSON WITH A ROLE IN CHROMOSOME STRUCTURER01GM050315 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI PARDUE, MARY-LOU · 1995 to 2006
$2.3M
An Evolutionary Link Between Telomeres and TransposonsR56GM050315 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI PARDUE, MARY-LOU · 2008 to 2008
$399k
NIGMS NIH HHS R01 GM050315NIGMS NIH HHS R56 GM050315
6 · The paper itself

Abstract

Reverse transcriptases have shaped genomes in many ways. A remarkable example of this shaping is found on telomeres of the genus Drosophila, where retrotransposons have a vital role in chromosome structure. Drosophila lacks telomerase; instead, three telomere-specific retrotransposons maintain chromosome ends. Repeated transpositions to chromosome ends produce long head to tail arrays of these elements. In both form and function, these arrays are analogous to the arrays of repeats added by telomerase to chromosomes in other organisms. Distantly related Drosophila exhibit this variant mechanism of telomere maintenance, which was established before the separation of extant Drosophila species. Nevertheless, the telomere-specific elements still have the hallmarks that characterize non-long terminal repeat (non-LTR) retrotransposons; they have also acquired characteristics associated with their roles at telomeres. These telomeric retrotransposons have shaped the Drosophila genome, but they have also been shaped by the genome. Here, we discuss ways in which these three telomere-specific retrotransposons have been modified for their roles in Drosophila chromosomes.

Indexed as

AnimalsCentromereChromosomesDrosophilaDrosophila melanogasterEuchromatinGene DeletionHeterochromatinModels, GeneticPhylogenyRetroelementsRNA, AntisenseTelomereY ChromosomeEuchromatinHeterochromatinRetroelementsRNA, Antisense

Identifiers

PMID21821789
PMCPMC3251079
OpenAlexW2029078135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.