Evidence map›Paper›PMID 21821765›Full record

ArticleApplied and environmental microbiology2011

Chemoenzymatic synthesis of N-acetyl-D-neuraminic acid from N-acetyl-D-glucosamine by using the spore surface-displayed N-acetyl-D-neuraminic acid aldolase.

Chao Gao, Xiaoman Xu, Xifeng Zhang, Bin Che, Cuiqing Ma, Jianhua Qiu, Fei Tao, Ping Xu

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Applications ofMicroorganisms · 2024
    Review
  2. Article
  3. Advances in engineeredSynthetic and systems biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chao GaoState Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Xiaoman Xu
Xifeng Zhang
Bin Che
Cuiqing Ma
Jianhua Qiu
Fei Tao
Ping Xu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemoenzymatic synthesis of N-acetyl-d-neuraminic acid from N-acetyl-d-glucosamine using the spore surface-displayed N-acetyl-d-neuraminic acid aldolase at a high concentration (53.9 g liter(-1)) was achieved in this study. Thus, displaying a target enzyme on the surface of spores might be an alternative for integration of biocatalytic conversion into chemical synthesis.

Indexed as

Gene ExpressionAcetylglucosamineAldehyde-LyasesBacillus subtilisBiosynthetic PathwaysBiotechnologyN-Acetylneuraminic AcidOrganisms, Genetically ModifiedRecombinant ProteinsSpores, BacterialAcetylglucosamineAldehyde-LyasesN-Acetylneuraminic Acidneuraminic acid aldolaseRecombinant Proteins

Identifiers

PMID21821765
PMCPMC3187080

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.