ArticleJournal of experimental botany2011
Global gene expression analysis of transgenic, mannitol-producing, and salt-tolerant Arabidopsis thaliana indicates widespread changes in abiotic and biotic stress-related genes.
Article in Journal of experimental botany, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Exploring the role of sugar alcohols in enhancing plant resilience to abiotic stresses.Protoplasma · 2026Review
- Mechanistic insights into the intrinsic drought resilience ofFrontiers in plant science · 2026Article
- Uracil-DNA Glycosylase fromInternational journal of molecular sciences · 2025Article
- Mining of Minor Disease Resistance Genes inInternational journal of molecular sciences · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
- Uncovering the wide protective responses inFrontiers in plant science · 2023Article
- Article
- Insights into the molecular aspects of salt stress tolerance in mycorrhizal plants.World journal of microbiology & biotechnology · 2022Review
- Low Mannitol Concentrations inPlants (Basel, Switzerland) · 2020Article
- Transcriptomic and Proteomic Analysis of Mannitol-metabolism-associated Genes in Saccharina japonica.Genomics, proteomics & bioinformatics · 2020Article
- Poly(ADP-Ribose) Polymerases in Plants and Their Human Counterparts: Parallels and Peculiarities.International journal of molecular sciences · 2019Review
- Alleviative role of exogenously applied mannitol in maize cultivars differing in chromium stress tolerance.Environmental science and pollution research international · 2019Article
- Influence of intergenotypic competition on multigenerational persistence of abiotic stress resistance transgenes in populations ofEvolutionary applications · 2018Article
- Deciphering drought-induced metabolic responses and regulation in developing maize kernels.Plant biotechnology journal · 2018Article
- Cloning of a functional mannose-6-phosphate reductase (M6PR) gene homolog from Egyptian celery plants (3 Biotech · 2017Article
- No Silver Bullet - Canonical Poly(ADP-Ribose) Polymerases (PARPs) Are No Universal Factors of Abiotic and Biotic Stress Resistance ofFrontiers in plant science · 2017Article
- Analysis of Copper-Binding Proteins in Rice Radicles Exposed to Excess Copper and Hydrogen Peroxide Stress.Frontiers in plant science · 2016Article
- Functional Identification and Characterization of Genes Cloned from Halophyte Seashore Paspalum Conferring Salinity and Cadmium Tolerance.Frontiers in plant science · 2016Article
- Comparative physiological, metabolomic, and transcriptomic analyses reveal mechanisms of improved abiotic stress resistance in bermudagrass [Cynodon dactylon (L). Pers.] by exogenous melatonin.Journal of experimental botany · 2015Article
- Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.Frontiers in microbiology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mannitol is a putative osmoprotectant contributing to salt tolerance in several species. Arabidopsis plants transformed with the mannose-6-phosphate reductase (M6PR) gene from celery were dramatically more salt tolerant (at 100 mM NaCl) as exhibited by reduced salt injury, less inhibition of vegetative growth, and increased seed production relative to the wild type (WT). When treated with 200 mM NaCl, transformants produced no seeds, but did bolt, and exhibited less chlorosis/necrosis and greater survival and dry weights than the WT. Without salt there were no M6PR effects on growth or phenotype, but expression levels of 2272 genes were altered. Many fewer differences (1039) were observed between M6PR and WT plants in the presence of salt, suggesting that M6PR pre-conditioned the plants to stress. Previous work suggested that mannitol is an osmoprotectant, but mannitol levels are invariably quite low, perhaps inadequate for osmoprotectant effects. In this study, transcriptome analysis reveals that the M6PR transgene activated the downstream abscisic acid (ABA) pathway by up-regulation of ABA receptor genes (PYL4, PYL5, and PYL6) and down-regulation of protein phosphatase 2C genes (ABI1 and ABI2). In the M6PR transgenic lines there were also increases in transcripts related to redox and cell wall-strengthening pathways. These data indicate that mannitol-enhanced stress tolerance is due at least in part to increased expression of a variety of stress-inducible genes.
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