ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2012
Human masseter muscle fiber type properties, skeletal malocclusions, and muscle growth factor expression.
Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between craniofacial skeletal patterns and anatomic characteristics of masticatory muscles: a systematic review and meta-analysis.Progress in orthodontics · 2024Pooled it
- Effect of botulinum toxin type A on masticatory function and musculoskeletal structure in rabbits.Scientific reports · 2025Article
- Optimizing Confocal Imaging Protocols for Muscle Fiber Typing in the Mouse Masseter Muscle.Bio-protocol · 2025Article
- Digital Occlusion Tracking by T-Scan Novus System in Bruxism Patients Treated With 3D Printed Occlusal Splints.International journal of dentistry · 2025Article
- Comprehensive Deciphering the Complexity of the Deep Bite: Insight from Animal Model to Human Subjects.Journal of personalized medicine · 2023Article
- Evaluation of factors related to morphological masseter muscle changes after preoperative orthodontic treatment in female patients with skeletal class III dentofacial deformities.BMC oral health · 2022Article
- The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype.Turkish journal of orthodontics · 2022Article
- Molecular imaging in masseter muscle observed by muscle function magnetic resonance imaging andClinical and experimental dental research · 2022Article
- A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription.Nature communications · 2021Article
- Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped?Seminars in orthodontics · 2017Article
- Oral motor and electromyographic characterization of adults with facial fractures: a comparison between different fracture severities.Clinics (Sao Paulo, Brazil) · 2017Observational
- ACTN3 R577X genotypes associate with Class II and deepbite malocclusions.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2014Article
- Nodal pathway genes are down-regulated in facial asymmetry.The Journal of craniofacial surgery · 2014Article
- Molecular motor MYO1C, acetyltransferase KAT6B and osteogenetic transcription factor RUNX2 expression in human masseter muscle contributes to development of malocclusion.Archives of oral biology · 2014Article
- Epigenetic influence of KAT6B and HDAC4 in the development of skeletal malocclusion.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2013Article
- Masseter function and skeletal malocclusion.Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeWe identified masseter muscle fiber type property differences in subjects with dentofacial deformities. PATIENTS AND
methodsSamples of masseter muscle were collected from 139 young adults during mandibular osteotomy procedures to assess mean fiber areas and percent tissue occupancies for the 4 fiber types that comprise the muscle. Subjects were classified into 1 of 6 malocclusion groups based on the presence of a skeletal Class II or III sagittal dimension malocclusion and either a skeletal open, deep, or normal bite vertical dimension malocclusion. In a subpopulation, relative quantities of the muscle growth factors IGF-I and GDF-8 gene expression were quantified by real-time polymerase chain reaction.
resultsFiber properties were not different in the sagittal malocclusion groups, but were very different in the vertical malocclusion groups (P ≤ .0004). There were significant mean fiber area differences for type II (P ≤ .0004) and type neonatal-atrial (P = .001) fiber types and for fiber percent occupancy differences for both type I-II hybrid fibers and type II fibers (P ≤ .0004). Growth factor expression differed by gender for IGF-I (P = .02) and GDF-8 (P < .01). The ratio of IGF-I:GDF-8 expression associates with type I and II mean fiber areas.
conclusionFiber type properties are very closely associated with variations in vertical growth of the face, with statistical significance for overall comparisons at P ≤ .0004. An increase in masseter muscle type II fiber mean fiber areas and percent tissue occupancies is inversely related to increases in vertical facial dimension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.