Evidence map›Paper›PMID 21821139›Full record

ReviewSeminars in cell & developmental biology2011

Moving in the right direction: how eukaryotic cells migrate along chemical gradients.

Huaqing Cai, Peter N Devreotes

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Role of Gα-MAPK interaction in mating ofMolecular biology of the cell · 2025
    Article
  2. Review
  3. Article
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  7. Article
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  15. The LTBJournal of cell science · 2018
    Article
  16. Decoding the chemotactic signal.Journal of leukocyte biology · 2018
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Huaqing CaiThe Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Peter N Devreotes

Funding

Temporal and Spatial Signaling in ChemotaxisR01GM034933 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 1987 to 2015
$8.8M
Signaling Networks in Chemotaxis and CytokinesisR37GM028007 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 2005 to 2014
$6.3M
SIGNAL TRANSDUCTION AND DICTYOSTELIUM DEVELOPMENTR01GM028007 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 1985 to 2004
$2.4M
NIGMS NIH HHS GM28007NIGMS NIH HHS GM34933NIGMS NIH HHS R01 GM028007NIGMS NIH HHS R01 GM034933NIGMS NIH HHS R37 GM028007
6 · The paper itself

Abstract

Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.

Indexed as

Cell MovementAnimalsChemotactic FactorsCytoskeletonEukaryotic CellsHumansIntracellular SpaceSignal TransductionChemotactic Factors

Identifiers

PMID21821139
PMCPMC4083813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.