Evidence map›Paper›PMID 21821120›Full record

ReviewCellular signalling2011

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass.

Craig A Goodman, David L Mayhew, Troy A Hornberger

Open access · greenAbstract readReview
In one paragraph

Review in Cellular signalling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. ETASPharmaceuticals (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Dietary fishmeal replacement byAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Dietary tea tree (Food science & nutrition · 2022
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Craig A GoodmanDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA. cgoodman2@wisc.edu
David L Mayhew
Troy A Hornberger
University of Wisconsin–Madison · USUniversity of Alabama at Birmingham · US

Funding

Mechanotransduction and the Regulation of Skeletal Muscle MassR01AR057347 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORNBERGER, TROY A · 2010 to 2019
$3.6M
Mechanotransduction and the Regulation of Skeletal Muscle MassR56AR057347 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORNBERGER, TROY A · 2022 to 2022
$270k
Mechanisms of Skeletal Muscle Satellite Cell Regulation in AgingF30AG031623 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MAYHEW, DAVID L. · 2007 to 2009
$89k
NIAMS NIH HHS AR057347NIAMS NIH HHS R01 AR057347NIAMS NIH HHS R56 AR057347NIA NIH HHS F30 AG031623NIA NIH HHS F30AG31623
6 · The paper itself

Abstract

The maintenance of muscle mass is critical for health and issues associated with the quality of life. Over the last decade, extensive progress has been made with regard to our understanding of the molecules that regulate skeletal muscle mass. Not surprisingly, many of these molecules are intimately involved in the regulation of protein synthesis and protein degradation [e.g. the mammalian target of rapamycin (mTOR), eukaryotic initiation factor 2B (eIF2B), eukaryotic initiation factor 3f (eIF3f) and the forkhead box O (FoxO) transcription factors]. It is also becoming apparent that molecules which sense, or control, the energetic status of the cell play a key role in the regulation of muscle mass [e.g. AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator-1 α (PGC1α)]. In this review we will attempt to summarize the current knowledge of how these molecules regulate skeletal muscle mass.

Indexed as

Adenylate KinaseAnimalsAutophagyEukaryotic Initiation Factor-2BEukaryotic Initiation Factor-3Forkhead Transcription FactorsGene Expression RegulationHumansMultiprotein ComplexesMuscle, SkeletalOrgan SizeProtein BiosynthesisProteolysisSignal TransductionTOR Serine-Threonine KinasesTrans-ActivatorsAdenylate KinaseEukaryotic Initiation Factor-2BEukaryotic Initiation Factor-3Forkhead Transcription FactorsMultiprotein ComplexesTOR Serine-Threonine KinasesTrans-Activators

Identifiers

PMID21821120
PMCPMC3744211
OpenAlexW1972023001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.