Trial reportThe Journal of allergy and clinical immunology2011
Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood.
Trial report in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 76 citations in OpenAlex.
- Allergic sensitization does not differ between childhood- and adolescent-onset asthma in women.The Journal of allergy and clinical immunology · 2020Trial
- Immune pathways and prenatal/perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration.Epigenetics · 2026Article
- The Association of Longitudinal Atopic Dermatitis Phenotypes and Attention-Deficit/Hyperactivity Disorder in Childhood.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Pet Exposure Is Associated with Altered Gut Microbiota and Higher Phospholipid and Protein Concentrations in the Breast Milk of Overweight/Obese Pregnant Women.Metabolites · 2026Article
- Sex-specific associations between hypertensive disorders in pregnancy and fetal and placental weight.Pediatric investigation · 2025Article
- Probiotic-Based Approaches for Sustainable Control of Infectious Risk in Mass Transport: Current Data and Future Perspectives.Microbial biotechnology · 2025Review
- Early-life risk factors which govern pro-allergic immunity.Seminars in immunopathology · 2024Review
- Impact of Spirometry Race-Correction on Preadolescent Black and White Children.The journal of allergy and clinical immunology. In practice · 2023Article
- Contributions of the early-life microbiome to childhood atopy and asthma development.Seminars in immunology · 2023Review
- The impact of prenatal dog keeping on infant gut microbiota development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Early-life gut microbiota and attention deficit hyperactivity disorder in preadolescents.Pediatric research · 2023Article
- When a birth cohort grows up: challenges and opportunities in longitudinal developmental origins of health and disease (DOHaD) research.Journal of developmental origins of health and disease · 2023Review
- Progression of C-reactive protein from birth through preadolescence varies by mode of delivery.Frontiers in pediatrics · 2023Article
- Race is a modifier between parental allergy and food allergy in offspring.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Pathogen Control in the Built Environment: A Probiotic-Based System as a Remedy for the Spread of Antibiotic Resistance.Microorganisms · 2022Article
- Microbial Sharing between Pediatric Patients and Therapy Dogs during Hospital Animal-Assisted Intervention Programs.Microorganisms · 2021Article
- The Phenotype of the Food-Allergic Patient.Immunology and allergy clinics of North America · 2021Review
- Moraxella-dominated pediatric nasopharyngeal microbiota associate with upper respiratory infection and sinusitis.PloS one · 2021Article
- Prenatal IgE as a Risk Factor for the Development of Childhood Neurodevelopmental Disorders.Frontiers in pediatrics · 2021Article
- Precision medicine in the era of artificial intelligence: implications in chronic disease management.Journal of translational medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe presence of pets in a home during the prenatal period and during early infancy has been associated with a lower prevalence of allergic sensitization and total IgE levels in middle childhood. No studies have examined the effect of pet exposure in a population-based cohort by using multiple early-life measures of serum total IgE.
objectiveWe sought to examine within-individual longitudinal trends in total IgE levels during early childhood and assess the effect of indoor prenatal pet exposure on those trends. Also, we sought to use a statistical method that was flexible enough to allow and account for unequally spaced study contacts and missing data.
methodsUsing the population-based Wayne County Health, Environment, Allergy and Asthma Longitudinal Study birth cohort (62% African American), we analyzed 1187 infants with 1 to 4 measurements of total IgE collected from birth to 2 years of age. Effects of pet exposure on the shape and trajectory of IgE levels were assessed by using a multilevel longitudinal model, accommodating repeated measures, missing data, and the precise time points of data collection.
resultsThe best-fit shape to the trajectory of IgE levels was nonlinear, with an accelerated increase before 6 months. Total IgE levels were lower across the entire early-life period when there was prenatal indoor pet exposure (P < .001). This effect was statistically significantly stronger in children delivered by means of cesarean section versus those delivered vaginally (P < .001 and P < .06, respectively) and in those born to non-African American (P < .001) versus African American (P < .3) mothers.
conclusionPet exposure and delivery mode might be markers of infant exposure to distinct microbiomes. The effect of exposures might vary by race, suggesting a differential effect by ancestry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.