ArticleNeurobiology of aging2012
Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 113 citations in OpenAlex.
- Article
- The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms.International journal of molecular sciences · 2024Review
- Mitigation of aging-related plasticity decline through taurine supplementation and environmental enrichment.Scientific reports · 2024Article
- Senolytic treatment alleviates doxorubicin-induced chemobrain.Aging cell · 2024Article
- Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging.Frontiers in aging neuroscience · 2024Article
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Environmental enrichment in middle age rats improves spatial and object memory discrimination deficits.Frontiers in behavioral neuroscience · 2024Article
- Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity.Frontiers in aging neuroscience · 2024Review
- Article
- Article
- Intense long-term training impairs brain health compared with moderate exercise: Experimental evidence and mechanisms.Annals of the New York Academy of Sciences · 2022Article
- Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach.Cells · 2022Article
- Article
- Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence.Molecular neurobiology · 2020Article
- Enriching hippocampal memory function in older adults through video games.Behavioural brain research · 2020Article
- Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.Science (New York, N.Y.) · 2020Article
- Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.Frontiers in aging neuroscience · 2020Article
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- The Quest for the Hippocampal Memory Engram: From Theories to Experimental Evidence.Frontiers in behavioral neuroscience · 2020Review
- Learning and aging affect neuronal excitability and learning.Neurobiology of learning and memory · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aged (20-22 months) male Fischer 344 rats were randomly assigned to sedentary (A-SED), environmentally-enriched (A-ENR), or exercise (A-EX) conditions. After 10-12 weeks of differential experience, the 3 groups of aged rats and young sedentary controls were tested for physical and cognitive function. Spatial discrimination learning and memory consolidation, tested on the water maze, were enhanced in environmentally-enriched compared with sedentary. A-EX exhibited improved and impaired performance on the cue and spatial task, respectively. Impaired spatial learning in A-EX was likely due to a bias in response selection associated with exercise training, as object recognition memory improved for A-EX rats. An examination of senescent hippocampal physiology revealed that enrichment and exercise reversed age-related changes in long-term depression (LTD) and long-term potentiation (LTP). Rats in the enrichment group exhibited an increase in cell excitability compared with the other 2 groups of aged animals. The results indicate that differential experience biased the selection of a spatial or a response strategy and factors common across the 2 conditions, such as increased hippocampal activity associated with locomotion, contribute to reversal of senescent synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.