Trial reportThe Journal of allergy and clinical immunology2011
Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone.
Trial report in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Effects of long-term inhaled corticosteroids on growth velocity and adult height in children with asthma: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Individualized therapy for persistent asthma in young children.The Journal of allergy and clinical immunology · 2016Trial
- Holy Grail: the journey towards disease modification in asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases.Italian journal of pediatrics · 2021Article
- Inhaled corticosteroids as treatment for adolescent asthma: effects on adult anxiety-related outcomes in a murine model.Psychopharmacology · 2021Article
- Pediatric asthma: Principles and treatment.Allergy and asthma proceedings · 2019Review
- Can early intervention in pediatric asthma improve long-term outcomes? A question that needs an answer.Pediatric pulmonology · 2019Review
- Growth Pattern, Resting Energy Expenditure, and Nutrient Intake of Children with Food Allergies.Nutrients · 2019Article
- Omalizumab and unmet needs in severe asthma and allergic comorbidities in Japanese children.Asia Pacific allergy · 2019Review
- Treating Pediatric Asthma According Guidelines.Frontiers in pediatrics · 2018Review
- Management of preschool recurrent wheezing and asthma: a phenotype-based approach.Current opinion in allergy and clinical immunology · 2017Review
- Benefits and Risks of Long-Term Asthma Management in Children: Where Are We Heading?Drug safety · 2017Review
- Adverse Effects of Nonsystemic Steroids (Inhaled, Intranasal, and Cutaneous): a Review of the Literature and Suggested Monitoring Tool.Current allergy and asthma reports · 2016Review
- Factors influencing growth effects of inhaled corticosteroids in children.The Journal of allergy and clinical immunology · 2015Review
- Emerging issues in pediatric asthma: gaps in EPR-3 guidelines for infants and children.Current allergy and asthma reports · 2014Review
- Asthma across the ages: knowledge gaps in childhood asthma.The Journal of allergy and clinical immunology · 2014Review
- Growth and nutritional concerns in children with food allergy.Current opinion in allergy and clinical immunology · 2013Review
- Inhaled corticosteroids in lung diseases.American journal of respiratory and critical care medicine · 2013Article
- International consensus on (ICON) pediatric asthma.Allergy · 2012Article
- Progress in the management of childhood asthma.Asia Pacific allergy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundThe effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial.
objectiveWe sought to determine the effect of daily inhaled corticosteroid given for 2 years on linear growth in preschool children with recurrent wheezing.
methodsChildren aged 2 and 3 years with recurrent wheezing and positive modified Asthma Predictive Index scores were randomized to a 2-year treatment period of chlorofluorocarbon-delivered fluticasone propionate (176 μg/d) or masked placebo delivered through a valved chamber with a mask and then followed for 2 years off study medication. Height growth determined by means of stadiometry was compared between treatment groups.
resultsIn the study cohort as a whole, the fluticasone group did not have significantly less linear growth than the placebo group (change in height from baseline difference, -0.2 cm; 95% CI, -1.1 to 0.6) 2 years after discontinuation of study treatment. In post hoc analyses children 2 years old who weighed less than 15 kg at enrollment and were treated with fluticasone had less linear growth compared with those treated with placebo (change in height from baseline difference, -1.6 cm; 95% CI, -2.8 to -0.4; P = .009).
conclusionLinear growth was not significantly different in high-risk preschool-aged children with recurrent wheezing treated with 176 μg/d chlorofluorocarbon-delivered fluticasone compared with placebo 2 years after fluticasone is discontinued. However, post hoc subgroup analyses revealed that children who are younger in age and of lesser weight relative to the entire study cohort had significantly less linear growth, possibly because of a higher relative fluticasone exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.