ArticleAmerican journal of rhinology & allergy
Characterization of specific antibody deficiency in adults with medically refractory chronic rhinosinusitis.
Article in American journal of rhinology & allergy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 74 citations in OpenAlex.
- Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency.Journal of inflammation research · 2026Review
- Diagnosis, Characteristics, and Outcome of Selective Anti-polysaccharide Antibody Deficiencies In A Retrospective Cohort of 55 Adult Patients.Journal of clinical immunology · 2025Observational
- Herbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella?Current allergy and asthma reports · 2025Review
- Consultation for Chronic Rhinosinusitis With Nasal Polyps and Asthma: Clinical Presentation, Diagnostic Workup, and Treatment Options.The journal of allergy and clinical immunology. In practice · 2024Review
- Monogenic Inborn Errors of Immunity with impaired IgG response to polysaccharide antigens but normal IgG levels and normal IgG response to protein antigens.Frontiers in pediatrics · 2024Review
- [Immunodeficiency in chronic rhinosinusitis : An important and often underestimated cause].HNO · 2019Article
- Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- How to Assess, Control, and Manage Uncontrolled CRS/Nasal Polyp Patients.Current allergy and asthma reports · 2017Review
- Immune deficiency in chronic rhinosinusitis: screening and treatment.Expert review of clinical immunology · 2017Review
- Specific Antibody Deficiency: Controversies in Diagnosis and Management.Frontiers in immunology · 2017Review
- Antibody deficiency in patients with frequent exacerbations of Chronic Obstructive Pulmonary Disease (COPD).PloS one · 2017Article
- Prevalence and pattern of humoral immunodeficiency in chronic refractory sinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Risk factors for chronic rhinosinusitis.Current opinion in allergy and clinical immunology · 2015Review
- Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- Good's syndrome, CVID, and selective antibody deficiency in patients with chronic rhinosinusitis.Current allergy and asthma reports · 2014Article
- Prevalence of and risk factors for oral human papillomavirus among young women in Costa Rica.The Journal of infectious diseases · 2013Article
- Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation.Genes and immunity · 2013Article
- Antibody deficiency in chronic rhinosinusitis: epidemiology and burden of illness.American journal of rhinology & allergy · 2013Review
- Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency.The journal of allergy and clinical immunology. In practiceArticle
- Low Baseline Pneumococcal Antibody Titers Predict Specific Antibody Deficiency, Increased Upper Respiratory Infections, and Allergy Sensitization.Allergy & rhinology (Providence, R.I.)Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSpecific antibody deficiency may predispose patients to recurrent respiratory tract infections. There is limited literature assessing specific antibody deficiency in chronic rhinosinusitis (CRS). This study evaluated the role of specific antibody deficiency in patients with CRS who have failed medical therapy.
methodsWe performed a retrospective chart review of patients with CRS who underwent functional endoscopic sinus surgery and had prior assessment for humoral immunodeficiency. Each patient's record was reviewed for serum quantitative immunoglobulin G (IgG) and IgA and anti-Streptococcus pneumoniae antibody titers measured at baseline and 6 weeks postvaccination with the 23-valent unconjugated pneumococcal vaccine. Clinical characteristics, including asthma, atopy, and nasal polyps, were recorded.
resultsOf the 129 CRS patients who met inclusion criteria, 93 (72%) had low baseline antipneumococcal titers. Fifteen (11.6%) patients were diagnosed with specific antibody deficiency based on an inadequate response to the pneumococcal polysaccharide vaccine. The group of patients with specific antibody deficiency had significantly lower serum IgA levels when compared with those patients with normal preimmunization titers (138 ± 67.3 versus 330 ± 356; p < 0.05). Patients with specific antibody deficiency had a significantly lower number of preimmunization protective antipneumococcal titers when compared with vaccine responders (1.41 versus 2.72; p < 0.0005).
conclusionThis retrospective study indicates that patients with medically refractory CRS may have a high prevalence of low preimmunization antipneumococcal titers and specific antibody deficiency. Furthermore, lower serum IgA levels identified in these specific antibody deficiency patients suggests that a prospective study to further characterize this relationship is warranted.
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