ArticleComparative medicine2011
Comparative bone anatomy of commonly used laboratory animals: implications for drug discovery.
Article in Comparative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Efficacy of photobiomodulation therapy on healing of ionizing irradiated bone: a systematic review of in vivo animal studies.Lasers in medical science · 2022Pooled it
- Longitudinal Computed Tomography Indicates No Negative Impact of OnabotulinumtoxinA on Mandibular Bone Density in a 12-Month, Double-Blind, Randomized, Repeat Treatment, Placebo-Controlled Study in Healthy Adults With Masseter Muscle Prominence.Aesthetic surgery journal · 2025Trial
- Intra-articular VEGF inhibition attenuates cartilage degeneration in a rat model of post-traumatic osteoarthritis: a pilot histopathological study.Rheumatology international · 2026Article
- Effects of different numbers of micro-osteoperforations on acceleration of orthodontic tooth movement and alveolar bone remodeling in rats.BMC oral health · 2026Article
- Beyond bisphosphonates: radiolabeled phosphopeptides for bone targeting.EJNMMI research · 2026Article
- Longitudinal and radial microgradients in porosity and canal diameter in femur bone and its implications for bone regeneration and bone repair implants.Frontiers in bioengineering and biotechnology · 2026Article
- Bioactive Surface Modifications on Bioresorbable Bone Screws: A Step Forward in Orthopedic Surgery.Polymers · 2025Article
- From flat bones to functional healing: redefining rodent calvarial defect models for translational bone regeneration research.Annals of medicine and surgery (2012) · 2025Article
- Enhancing the Accuracy of Pedicle Screw Placement Using 3D-Printed Screw-Guiding Techniques in the Lumbosacral Region for Small Breed Dogs: A Cadaveric Study.Animals : an open access journal from MDPI · 2024Article
- The Effect of Bone Mechanical Stress Caused by Electrical Stimulation-Induced Muscle Contraction on Osteocalcin Secretion.Biology · 2024Article
- Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models.Life (Basel, Switzerland) · 2024Article
- Revisiting the Historic Strontium-90 Ingestion Beagle Study Conducted at the University of California Davis: Opportunity in Archival Materials.Radiation research · 2024Article
- Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades.Journal of functional biomaterials · 2024Review
- Lamellar Septa-like Structured Carbonate Apatite Scaffolds with Layer-by-Layer Fracture Behavior for Bone Regeneration.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- The efficiency of genetically modified mesenchymal stromal cells combined with a functionally graded scaffold for bone regeneration in corticosteroid-induced osteonecrosis of the femoral head in rabbits.Journal of biomedical materials research. Part A · 2023Article
- Bone Morphogenic Protein and Mesenchymal Stem Cells to Regenerate Bone in Calvarial Defects: A Systematic Review.Journal of clinical medicine · 2023Review
- Biological effect of bone marrow mesenchymal stem cell- derived extracellular vesicles on the structure of alveolar bone in rats with glucocorticoid-induced osteoporosis.BMC musculoskeletal disorders · 2023Article
- Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration.Computational and structural biotechnology journal · 2023Article
- Topology Optimization-Based Localized Bone Microstructure Reconstruction for Image Resolution Enhancement: Accuracy and Efficiency.Bioengineering (Basel, Switzerland) · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To accommodate functional demands, the composition and organization of the skeleton differ among species. Microcomputed tomography has improved our ability markedly to assess structural parameters of cortical and cancellous bone. The current study describes differences in cortical and cancellous bone structure, bone mineral density, and morphology (geometry) at the proximal femur, proximal femoral diaphysis, lumbar vertebrae, and mandible in mice, rats, rabbits, dogs, and nonhuman primates. This work enhances our understanding of bone gross and microanatomy across lab animal species and likely will enable scientists to select the most appropriate species and relevant bone sites for research involving skeleton. We evaluated the gross and microanatomy of the femora head and neck, lumbar spine, and mandible and parameters of cancellous bone, including trabecular number, thickness, plate separation, and connectivity among species. The skeletal characteristics of rabbits, including a very short femoral neck and small amounts of cancellous bone at the femoral neck, vertebral body, and mandible, seem to make this species the least desirable for preclinical research of human bone physiology; in comparison, nonhuman primates seem the most applicable for extrapolation of data to humans. However, rodent (particularly rat) models are extremely useful for conducting basic research involving the skeleton and represent reliable and affordable alternatives to dogs and nonhuman primates. Radiology and microcomputed tomography allow for reliable evaluation of bone morphology, microarchitecture, and bone mineral density in preclinical and clinical environments.
Indexed as
Identifiers
21819685PMC3060425W1278340792What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.