ArticleComparative medicine2011
Diabetes enhances dental caries and apical periodontitis in caries-susceptible WBN/KobSlc rats.
Article in Comparative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis.Clinical oral investigations · 2016Pooled it
- Impact of detection criteria on coronal and root caries estimates in adults with and without type 2 diabetes mellitus.Clinical oral investigations · 2022Article
- Odontogenic gene expression profile of human dental pulp-derived cells under high glucose influence: a microarray analysis.Journal of applied oral science : revista FOB · 2021Article
- Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2020Article
- Evaluating All Potential Oral Complications of Diabetes Mellitus.Frontiers in endocrinology · 2019Review
- Type 2 diabetes as a risk indicator for dental caries in Korean adults: the 2011-2012 Korea national health and nutrition examination survey.Community dental health · 2017Article
- Hyperglycemia simultaneously induces initial caries development and enhances spontaneous occlusal surface wear in molar teeth related to parotid gland disorder in alloxan-induced diabetic rats.Journal of toxicologic pathology · 2017Article
- Assessment of Alloxan-Induced Diabetic Rats as a Periodontal Disease Model Using a Selective Cyclooxygenase (COX)-2 Inhibitor.Journal of toxicologic pathology · 2014Article
- The effect of food hardness on the development of dental caries in alloxan-induced diabetic rats.Journal of diabetes research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many epidemiologic studies have suggested that diabetes may be an important risk factor for periodontal disease. To determine whether diabetes induces or enhances periodontal disease or dental caries, dental tissue from diabetic male and nondiabetic female WBN/KobSlc rats and male and female age-matched nondiabetic F344 rats was analyzed morphologically and morphometrically for these 2 types of lesions. Soft X-ray examination revealed that the incidence and severity of both molar caries and alveolar bone resorption were much higher in male WBN/KobSlc rats with chronic diabetes than in nondiabetic female rats of the same strain. Histopathologic examination showed that dental caries progressed from acute to subacute inflammation due to bacterial infections and necrosis in the pulp when the caries penetrated the dentin. In the most advanced stage of dental caries, inflammatory changes caused root abscess and subsequent apical periodontitis, with the formation of granulation tissue around the dental root. Inflammatory changes resulted in resorption of alveolar bone and correlated well with the severity of molar caries. Our results suggest that diabetic conditions enhance dental caries in WBN/KobSlc rats and that periodontal lesions may result from the apical periodontitis that is secondary to dental caries.
Indexed as
Identifiers
21819682PMC3060429W159223513What OpenQuestion holds
Registered trials
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