Evidence map›Paper›PMID 21819304›Full record

ReviewExpert review of proteomics2011

Unraveling pancreatic islet biology by quantitative proteomics.

Jian-Ying Zhou, Geoffrey P Dann, Chong Wee Liew, Richard D Smith, Rohit N Kulkarni, Wei-Jun Qian

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jian-Ying ZhouBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Geoffrey P Dann
Chong Wee Liew
Richard D Smith
Rohit N Kulkarni
Wei-Jun Qian
Pacific Northwest National Laboratory · USHarvard University · USJoslin Diabetes Center · US

Funding

WORKSHOP AND TRAINING ACTIVITIESP41RR018522 · NCRR · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2003 to 2011
$25.1M
Proteomics Studies of Type 2 Diabetes Using Knockout Mouse ModelsR01DK074795 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2008 to 2012
$2.0M
NCRR NIH HHS P41 RR018522NCRR NIH HHS RR018522NIDDK NIH HHS R01 DK074795NIDDK NIH HHS R01DK074795
6 · The paper itself

Abstract

The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathogenesis underlying both Type 1 and Type 2 diabetes. Over the past 5 years, emerging proteomic technologies have been applied to dissect the signaling pathways that regulate islet functions and gain an understanding of the mechanisms of islet dysfunction relevant to diabetes. Herein, we briefly review some of the recent quantitative proteomic studies involving pancreatic islets geared towards gaining a better understanding of islet biology relevant to metabolic diseases.

Indexed as

AnimalsHumansIslets of LangerhansProteomics

Identifiers

PMID21819304
PMCPMC3160816
OpenAlexW2062699806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.