ReviewAnnual review of cell and developmental biology2011
Optogenetic control of cells and circuits.
Review in Annual review of cell and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed.
- Decoding darkness by seeking photoreceptor functions with and without light.Nature plants · 2026Review
- Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research.Nucleic acids research · 2025Article
- Sodium-Selective Channelrhodopsins.Cells · 2024Review
- In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning.Science advances · 2024Article
- Blue and Green Light Responsive Caged Glutamate.Journal of photochemistry and photobiology. A, Chemistry · 2024Article
- Neural mass modeling for the masses: Democratizing access to whole-brain biophysical modeling with FastDMF.Network neuroscience (Cambridge, Mass.) · 2024Article
- Light-Controlled Modulation and Analysis of Neuronal Functions.International journal of molecular sciences · 2022Article
- An Optogenetic Tool to Raise Intracellular pH in Single Cells and Drive Localized Membrane Dynamics.Journal of the American Chemical Society · 2021Article
- The PHY Domain Dimer Interface of Bacteriophytochromes Mediates Cross-talk between Photosensory Modules and Output Domains.Journal of molecular biology · 2021Article
- Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- A LexA-based yeast two-hybrid system for studying light-switchable interactions of phytochromes with their interacting partners.aBIOTECH · 2021Article
- Article
- History and Perspectives of Ion-Transporting Rhodopsins.Advances in experimental medicine and biology · 2021Review
- Engineering of stimuli-responsive lipid-bilayer membranes using supramolecular systems.Nature reviews. Chemistry · 2021Review
- Current Topics of Optogenetics for Medical Applications Toward Therapy.Advances in experimental medicine and biology · 2021Article
- Controlling the behaviour of Drosophila melanogaster via smartphone optogenetics.Scientific reports · 2020Article
- Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity-at Depth and in Real Time.Neuron · 2020Review
- Reversible photo-control over transmembrane anion transport using visible-light responsive supramolecular carriers.Chemical science · 2020Article
- Expanding the Chemogenetic Toolbox by Circular Permutation.Journal of molecular biology · 2020Article
- Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The absorption of light by bound or diffusible chromophores causes conformational rearrangements in natural and artificial photoreceptor proteins. These rearrangements are coupled to the opening or closing of ion transport pathways, the association or dissociation of binding partners, the enhancement or suppression of catalytic activity, or the transcription or repression of genetic information. Illumination of cells, tissues, or organisms engineered genetically to express photoreceptor proteins can thus be used to perturb biochemical and electrical signaling with exquisite cellular and molecular specificity. First demonstrated in 2002, this principle of optogenetic control has had a profound impact on neuroscience, where it provides a direct and stringent means of probing the organization of neural circuits and of identifying the neural substrates of behavior. The impact of optogenetic control is also beginning to be felt in other areas of cell and organismal biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.