Evidence map›Paper›PMID 21819153›Full record

ArticleJournal of the American Chemical Society2011

Expanding the genetic code of an animal.

Sebastian Greiss, Jason W Chin

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed.

  1. Review
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  3. Article
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  11. Article
  12. Review
  13. Review
  14. Expanding the Genetic Code ofACS chemical biology · 2024
    Article
  15. Article
  16. Evolution and synthetic biology.Current opinion in microbiology · 2023
    Review
  17. Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid.Protein science : a publication of the Protein Society · 2022
    Article
  18. Article
  19. Article
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sebastian GreissMedical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.
Jason W Chin

Funding

Medical Research Council MC_U105181009Medical Research Council MC_UP_A024_1008
6 · The paper itself

Abstract

Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

Indexed as

Genetic CodeAmino AcidsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA, BacterialAmino AcidsCaenorhabditis elegans ProteinsDNA, Bacterial

Identifiers

PMID21819153
PMCPMC3168933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.