Evidence map›Paper›PMID 21818753›Full record

ArticleCurrent protocols in toxicology2011

Measurement of peroxiredoxin activity.

Kimberly J Nelson, Derek Parsonage

Abstract read
In one paragraph

Article in Current protocols in toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 73 citations in OpenAlex.

  1. Asphaltene biotransformation by a novel enzyme thiol peroxidase fromApplied and environmental microbiology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Prdx1 Interacts with ASK1 upon Exposure to HAntioxidants (Basel, Switzerland) · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Article
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  17. Article
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  19. Article
  20. The Human PathogenFrontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kimberly J NelsonDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Derek Parsonage
Wake Forest University · US

Funding

Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox SystemsR01GM050389 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 1994 to 2013
$4.8M
Profiling of cysteine sulfenic acids in redox signalingF32GM074537 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NELSON, KIMBERLY J · 2005 to 2006
$93k
NIGMS NIH HHS F32 GM074537NIGMS NIH HHS R01 GM050389
6 · The paper itself

Abstract

Peroxiredoxins are cysteine-dependent peroxidases that react with hydrogen peroxide, larger hydroperoxide substrates, and peroxynitrite. Protocols are provided to measure Prx activity with peroxide by (1) a coupled reaction with NADPH, thioredoxin reductase, and thioredoxin, (2) the direct monitoring of thioredoxin oxidation, (3) competition with horseradish peroxidase, and (4) peroxide consumption using the FOX assay.

Indexed as

AnimalsEnzyme AssaysHumansPeroxiredoxinsSubstrate SpecificityPeroxiredoxins

Identifiers

PMID21818753
PMCPMC3703631
OpenAlexW1551537123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.