Evidence map›Paper›PMID 21818732›Full record

ArticleAmerican journal of perinatology2012

Impact of smoking during pregnancy on functional coagulation testing.

Donna Dizon-Townson, Connie Miller, Valerija Momirova, Baha Sibai, Catherine Y Spong, George Wendel, Katharine Wenstrom, Philip Samuels, Steve Caritis, Yoram Sorokin and 5 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in American journal of perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 1 country.

Donna Dizon-TownsonDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, USA. donna.dizon-townson@imail.org
Connie Miller
Valerija Momirova
Baha Sibai
Catherine Y Spong
George Wendel
Katharine Wenstrom
Philip Samuels
Steve Caritis
Yoram Sorokin
Menachem Miodovnik
Mary J O'Sullivan
Deborah Conway
Ronald J Wapner
Steven G Gabbe
The Ohio State University · USUniversity of Cincinnati · USBrown University · USCenters for Disease Control and Prevention · USColumbia University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USMagee-Womens Research Institute · USThe University of Texas Health Science Center at Houston · USThe University of Texas Southwestern Medical Center · USUniversity of Miami · USUniversity of Utah · USWayne State University · US

Funding

MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
NICHD Maternal Fetal Medicine Units NetworkU10HD034116 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CASEY, BRIAN M · 1996 to 2015
$19.3M
NICHD Maternal Fetal Medicine Units NetworkU10HD034208 · NICHD · UNIVERSITY OF UTAH · PI VARNER, MICHAEL W. · 1996 to 2015
$16.6M
NICHD Maternal Fetal Medicine Units NetworkU10HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TITA, ALAN THEVENET N. · 1991 to 2015
$12.8M
NICHD Maternal Fetal Medicine Units NetworkU10HD027917 · NICHD · WAYNE STATE UNIVERSITY · PI GONIK, BERNARD · 1991 to 2015
$8.2M
NICHD Maternal Fetal Medicine Units NetworkU10HD027915 · NICHD · OHIO STATE UNIVERSITY · PI IAMS, JAY · 1992 to 2015
$7.7M
NICHD Maternal Fetal Medicine Units NetworkU10HD021410 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI CARITIS, STEVE N · 1991 to 2015
$7.2M
NICHD MATERNAL FETAL MEDICINE UNITS NETWORKU10HD034136 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI FITZSIMMONS, JACK · 1996 to 2007
$5.6M
NICHD MATERNAL FETAL MEDICINE UNITS NETWORKU10HD027860 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HARPER, MARGARET ANN · 1991 to 2006
$3.7M
UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical CentersUG1HD034208 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Torri D Metz · 2016 to 2026
$3.4M
NICHD Maternal Fetal Medicine Units NetworkUG1HD027915 · NICHD · OHIO STATE UNIVERSITY · PI Maged Costantine · 2016 to 2026
$3.3M
NICHD Maternal-Fetal Medicine Units NetworksUG1HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALAN THEVENET N. TITA · 2016 to 2026
$3.0M
NICHD NIH HHS HD21410NICHD NIH HHS HD21414NICHD NIH HHS HD27860NICHD NIH HHS HD27861NICHD NIH HHS HD27869NICHD NIH HHS HD27915NICHD NIH HHS HD27917NICHD NIH HHS HD34116NICHD NIH HHS HD34136NICHD NIH HHS HD34208NICHD NIH HHS HD34210NICHD NIH HHS U01 HD036801NICHD NIH HHS U01-HD36801NICHD NIH HHS U10 HD021410NICHD NIH HHS U10 HD027860NICHD NIH HHS U10 HD027869NICHD NIH HHS U10 HD027905NICHD NIH HHS U10 HD027915NICHD NIH HHS U10 HD027917NICHD NIH HHS U10 HD034116NICHD NIH HHS U10 HD034122NICHD NIH HHS U10 HD034136NICHD NIH HHS U10 HD034208
6 · The paper itself

Abstract

Compounds that are systemically absorbed during the course of cigarette smoking, and their metabolites, affect the coagulation system and cause endothelial dysfunction, dyslipidemia, and platelet activation leading to a prothrombotic state. In addition, smoking increases the activity of fibrinogen, homocysteine, and C-reactive protein. We hypothesize that smoking may affect functional coagulation testing during pregnancy. A secondary analysis of 371 women pregnant with a singleton pregnancy and enrolled in a multicenter, prospective observational study of complications of factor V Leiden mutation subsequently underwent functional coagulation testing for antithrombin III, protein C antigen and activity, and protein S antigen and activity. Smoking was assessed by self-report at time of enrollment (<14 weeks). None of the functional coagulation testing results was altered by maternal smoking during pregnancy. Smoking does not affect the aforementioned functional coagulation testing results during pregnancy.

Indexed as

AdultAntithrombin IIIBlood CoagulationBlood Coagulation TestsBlood ProteinsFactor VFemaleHumansPregnancyPregnancy Complications, HematologicProspective StudiesProtein CProtein SSmokingAntithrombin IIIBlood ProteinsFactor VProtein CProtein S

Identifiers

PMID21818732
PMCPMC3770153
OpenAlexW2018891831

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.