Evidence map›Paper›PMID 21818701›Full record

ReviewSeminars in immunopathology2012

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum.

Adriana Vieira-de-Abreu, Robert A Campbell, Andrew S Weyrich, Guy A Zimmerman

Abstract readReview
In one paragraph

Review in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Antiplatelet agents for the treatment of deep venous thrombosis.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. [Pulmonary innate immune response in Sars-cov-2 infection]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2022
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Exploring Clinical Characteristics and Risk Factors ofJournal of inflammation research · 2026
    Article
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  11. Review
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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adriana Vieira-de-AbreuDepartment of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Robert A Campbell
Andrew S Weyrich
Guy A Zimmerman

Funding

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
TRANSLATIONAL EVENTS IN PLATELETSR01HL066277 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2001 to 2012
$3.8M
Molecular Interactions of Myeloid Cells with EndotheliumR37HL044525 · NHLBI · UNIVERSITY OF UTAH · PI ZIMMERMAN, GUY A. · 2004 to 2013
$3.5M
TISSUE FACTOR GENE REGULATION IN MONOCYTESR01HL048872 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACKMAN, NIGEL · 1992 to 2009
$2.9M
Novel Thrombotic & Inflammatory Mechanisms of Venous Thromboembolism in ElderlyR01HL092746 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2007 to 2010
$2.0M
Novel Activities of Platelets in Acute Lung InjuryR01HL091754 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2008 to 2011
$1.5M
MOLECULAR INTERACTIONS OF MYELOID CELLS WITH ENDOTHELIUMR01HL044525 · NHLBI · UNIVERSITY OF UTAH · PI ZIMMERMAN, GUY A. · 1990 to 2003
$1.2M
Novel Thrombotic and Inflammatory Activities of Platelets in SepsisR01HL090870 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S, ZIMMERMAN, GUY A. · 2009 to 2010
$1.1M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR011234 · NCRR · UNIVERSITY OF UTAH · PI MATSEN, JOHN M · 1995 to 1995
–
NCRR NIH HHS C06 RR011234NCRR NIH HHS ULI-RR025764NHLBI NIH HHS HL044525NHLBI NIH HHS HL048872NHLBI NIH HHS HL066277NHLBI NIH HHS HL090870NHLBI NIH HHS HL091754NHLBI NIH HHS HL092746NHLBI NIH HHS R01 HL044525NHLBI NIH HHS R01 HL048872NHLBI NIH HHS R01 HL066277NHLBI NIH HHS R01 HL090870NHLBI NIH HHS R01 HL091754NHLBI NIH HHS R01 HL092746NHLBI NIH HHS R37 HL044525PHS HHS K231440921
6 · The paper itself

Abstract

Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on interactions between inflammatory, immune, and hemostatic activities of these anucleate but complex and versatile cells. The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.

Indexed as

Adaptive ImmunityImmunity, InnateAnimalsBlood PlateletsHemostasisHumansInflammationThrombosis

Identifiers

PMID21818701
PMCPMC4334392

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.