Evidence map›Paper›PMID 21818697›Full record

ReviewJournal of cardiovascular translational research2011

Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction.

Kathy Yuan Ye, Lauren Deems Black

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Heart Slices to Model Cardiac Physiology.Frontiers in pharmacology · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Cardiovascular Bio-Engineering: Current State of the Art.Journal of cardiovascular translational research · 2017
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Model systems for cardiovascular regenerative biology.Cold Spring Harbor perspectives in medicine · 2013
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kathy Yuan YeDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA. kathy.ye@tufts.edu
Lauren Deems Black
Tufts University · US

Funding

Restoring LV Function Post-MI Using Fibrin-Gel Based Engineered MyocardiumR00HL093358 · NHLBI · TUFTS UNIVERSITY MEDFORD · PI BLACK III, LAUREN D. · 2010 to 2012
$747k
NHLBI NIH HHS R00 HL093358
6 · The paper itself

Abstract

Tissue-engineered cardiac constructs are a high potential therapy for treating myocardial infarction. These therapies have the ability to regenerate or recreate functional myocardium following the infarction, restoring some of the lost function of the heart and thereby preventing congestive heart failure. Three key factors to consider when developing engineered myocardial tissue include the cell source, the choice of scaffold, and the use of biomimetic culture conditions. This review details the various biomaterials and scaffold types that have been used to generate engineered myocardial tissues as well as a number of different methods used for the fabrication and culture of these constructs. Specific bioreactor design considerations for creating myocardial tissue equivalents in vitro, such as oxygen and nutrient delivery as well as physical stimulation, are also discussed. Lastly, a brief overview of some of the in vivo studies that have been conducted to date and their assessment of the functional benefit in repairing the injured heart with engineered myocardial tissue is provided.

Indexed as

RegenerationStem Cell TransplantationTissue EngineeringAnimalsHumansMyocardial InfarctionMyocardiumRegenerative Medicine

Identifiers

PMID21818697
PMCPMC3182851
OpenAlexW1966142024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.