ArticleBehavior genetics2012
Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood.
Article in Behavior genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A Prospective Cohort Study of Influences on Externalizing Behaviors Across Childhood: Results From a Nurse Home Visiting Randomized Controlled Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Trial
- Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.medRxiv : the preprint server for health sciences · 2025Article
- Are Depressive and Anxiety Symptoms Differentially Associated with Alcohol Use Behaviors: Multivariate Behavioral Genetic Analyses.Behavior genetics · 2025Article
- Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife.Development and psychopathology · 2025Article
- Etiology and correlates of alcohol misuse in early midlife.Alcohol, clinical & experimental research · 2025Article
- Genetic risk for trait aggression and alcohol use predict unique facets of alcohol-related aggression.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- Prevalence and heritability of alcohol use disorders in 18-year old Swedish twins.Nordisk alkohol- & narkotikatidskrift : NAT · 2023Article
- Influence of Age and Genetic Background on Ethanol Intake and Behavioral Response Following Ethanol Consumption and During Abstinence in a Model of Alcohol Abuse.Frontiers in behavioral neuroscience · 2022Article
- Maternal Parenting Behaviors Amplify Environmental Influences on Developmental Trajectories of Alcohol Use During Adolescence.Behavior genetics · 2021Article
- Intersection of familial risk and environmental social control on high-risk drinking and alcohol dependence in a US national sample of adults.Addictive behaviors · 2021Article
- Genetic risk for schizophrenia is associated with substance use in emerging adulthood: an event-level polygenic prediction model.Psychological medicine · 2019Article
- Genetic and environmental influences on developmental trajectories of adolescent alcohol use.European child & adolescent psychiatry · 2019Article
- Developmental Etiologies of Alcohol Use and Their Relations to Parent and Peer Influences Over Adolescence and Young Adulthood: A Genetically Informed Approach.Alcoholism, clinical and experimental research · 2017Article
- A National Swedish Longitudinal Twin-Sibling Study of alcohol use disorders among males.Addiction (Abingdon, England) · 2017Article
- Stability and change in etiological factors for alcohol use disorder and major depression.Journal of abnormal psychology · 2017Article
- The association between personality disorders with alcohol use and misuse: A population-based twin study.Drug and alcohol dependence · 2017Article
- Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice.Genes, brain, and behavior · 2017Article
- Alcohol Misuse Across the Lifespan: Insights from Developmental Studies in Behavior Genetics.Policy insights from the behavioral and brain sciences · 2017Article
- A Functional Vesicular Monoamine Transporter 1 (VMAT1) Gene Variant Is Associated with Affect and the Prevalence of Anxiety, Affective, and Alcohol Use Disorders in a Longitudinal Population-Representative Birth Cohort Study.The international journal of neuropsychopharmacology · 2016Article
- Genomic influences on alcohol problems in a population-based sample of young adults.Addiction (Abingdon, England) · 2015Article
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Authors and funding
9 authors.
Funding
Abstract
Relatively little is known about how genetic influences on alcohol abuse and dependence (AAD) change with age. We examined the change in influence of genetic and environmental factors which explain symptoms of AAD from adolescence into early adulthood. Symptoms of AAD were assessed using the four AAD screening questions of the CAGE inventory. Data were obtained up to six times by self-report questionnaires for 8,398 twins from the Netherlands Twin Register aged between 15 and 32 years. Longitudinal genetic simplex modeling was performed with Mx. Results showed that shared environmental influences were present for age 15-17 (57%) and age 18-20 (18%). Unique environmental influences gained importance over time, contributing 15% of the variance at age 15-17 and 48% at age 30-32. At younger ages, unique environmental influences were largely age-specific, while at later ages, age-specific influences became less important. Genetic influences on AAD symptoms over age could be accounted for by one factor, with the relative influence of this factor differing across ages. Genetic influences increased from 28% at age 15-17 to 58% at age 21-23 and remained high in magnitude thereafter. These results are in line with a developmentally stable hypothesis that predicts that a single set of genetic risk factors acts on symptoms of AAD from adolescence into young adulthood.
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