ArticleBiomechanics and modeling in mechanobiology2012
Effects of wall shear stress and its gradient on tumor cell adhesion in curved microvessels.
Article in Biomechanics and modeling in mechanobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Modeling of Tumor Cell Adhesion, Extravasation, and Sorting in a Microvascular System.Advances in experimental medicine and biology · 2026Article
- Tumor Metastasis in the Microcirculation.Advances in experimental medicine and biology · 2026Review
- A Novel in vivo Rat Mesentery Model for Studying Tumor Spheroid-Induced Microvascular Remodeling.Journal of vascular research · 2025Article
- Computational analysis of cancer cell adhesion in curved vessels affected by wall shear stress for prediction of metastatic spreading.Frontiers in bioengineering and biotechnology · 2024Article
- Modeling Physical Forces Experienced by Cancer and Stromal Cells Within Different Organ-Specific Tumor Tissue.IEEE journal of translational engineering in health and medicine · 2024Article
- The role of adhesive receptor patterns on cell transport in complex microvessels.Biomechanics and modeling in mechanobiology · 2022Article
- Margination and adhesion dynamics of tumor cells in a real microvascular network.PLoS computational biology · 2021Article
- Investigating the Interaction Between Circulating Tumor Cells and Local HydrodynamicsCellular and molecular bioengineering · 2020Article
- The mechanical responses of advecting cells in confined flow.Biomicrofluidics · 2020Review
- Localization of Rolling and Firm-Adhesive Interactions Between Circulating Tumor Cells and the Microvasculature Wall.Cellular and molecular bioengineering · 2020Article
- Gradient fluid shear stress regulates migration of osteoclast precursors.Cell adhesion & migration · 2019Article
- Three-dimensional distribution of wall shear stress and its gradient in red cell-resolved computational modeling of blood flow in in vivo-like microvascular networks.Physiological reports · 2019Article
- Fluid shear stress and tumor metastasis.American journal of cancer research · 2018Review
- Effects of flowing RBCs on adhesion of a circulating tumor cell in microvessels.Biomechanics and modeling in mechanobiology · 2017Article
- Numerical simulation of a single cell passing through a narrow slit.Biomechanics and modeling in mechanobiology · 2016Article
- Inhibition of endothelial nitric oxide synthase decreases breast cancer cell MDA-MB-231 adhesion to intact microvessels under physiological flows.American journal of physiology. Heart and circulatory physiology · 2016Article
- Automatic Classification and Quantification of Cell Adhesion Locations on the Endothelium.Annals of biomedical engineering · 2015Article
- Metastasis of circulating tumor cells: favorable soil or suitable biomechanics, or both?Cell adhesion & migration · 2015Review
- Differential arrest and adhesion of tumor cells and microbeads in the microvasculature.Biomechanics and modeling in mechanobiology · 2014Article
- Analysis of a high-throughput cone-and-plate apparatus for the application of defined spatiotemporal flow to cultured cells.Biotechnology and bioengineering · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Tumor cell adhesion to vessel walls in the microcirculation is one critical step in cancer metastasis. In this paper, the hypothesis that tumor cells prefer to adhere at the microvessels with localized shear stresses and their gradients, such as in the curved microvessels, was examined both experimentally and computationally. Our in vivo experiments were performed on the microvessels (post-capillary venules, 30-50 μm diameter) of rat mesentery. A straight or curved microvessel was cannulated and perfused with tumor cells by a glass micropipette at a velocity of ~1mm/s. At less than 10 min after perfusion, there was a significant difference in cell adhesion to the straight and curved vessel walls. In 60 min, the averaged adhesion rate in the curved vessels (n = 14) was ~1.5-fold of that in the straight vessels (n = 19). In 51 curved segments, 45% of cell adhesion was initiated at the inner side, 25% at outer side, and 30% at both sides of the curved vessels. To investigate the mechanical mechanism by which tumor cells prefer adhering at curved sites, we performed a computational study, in which the fluid dynamics was carried out by the lattice Boltzmann method , and the tumor cell dynamics was governed by the Newton's law of translation and rotation. A modified adhesive dynamics model that included the influence of wall shear stress/gradient on the association/dissociation rates of tumor cell adhesion was proposed, in which the positive wall shear stress/gradient jump would enhance tumor cell adhesion while the negative wall shear stress/gradient jump would weaken tumor cell adhesion. It was found that the wall shear stress/gradient, over a threshold, had significant contribution to tumor cell adhesion by activating or inactivating cell adhesion molecules. Our results elucidated why the tumor cell adhesion prefers to occur at the positive curvature of curved microvessels with very low Reynolds number (in the order of 10(-2)) laminar flow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.