ArticleJournal of gastroenterology2011
Clinical significance of salvage esophagectomy for remnant or recurrent cancer following definitive chemoradiotherapy.
Article in Journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Curative endoscopic submucosal dissection for esophageal squamous cell carcinoma after chemoradiotherapy for pharyngeal cancer: A case report.World journal of gastrointestinal oncology · 2025Article
- German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.ESMO gastrointestinal oncology · 2025Review
- Efficacy of thoracotomy and thoracoscopic-assisted esophageal surgery in conversion and salvage surgeries: a retrospective study.World journal of surgical oncology · 2022Article
- It's not always too late: a case for minimally invasive salvage esophagectomy.Surgical endoscopy · 2021Article
- Salvage treatment after definitive chemoradiotherapy for esophageal squamous cell carcinoma.Annals of gastroenterological surgery · 2021Review
- Cardiac tamponade in a long-term survival esophageal cancer patient after esophageal bypass and chemoradiotherapy: a case report.Clinical journal of gastroenterology · 2020Article
- Endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer: choice of new approach.Radiation oncology (London, England) · 2018Article
- Prognostic Factors of Salvage Esophagectomy for Residual or Recurrent Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy.World journal of surgery · 2018Article
- Article
- Salvage esophagectomy with pancreatectomy for local recurrence of thoracic esophageal cancer after definitive chemoradiotherapy: A case report.International journal of surgery case reports · 2018Article
- Efficacy and Safety of Endoscopic Resection Followed by Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma: A Retrospective Study.Clinical and translational gastroenterology · 2017Article
- Salvage esophagectomy: safe therapeutic strategy?Journal of thoracic disease · 2017Review
- Texture analysis ofEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Positive esophageal proximal resection margin: an important prognostic factor for esophageal cancer that warrants adjuvant therapy.Journal of thoracic disease · 2016Article
- Transnasal inner drainage: an option for managing anastomotic leakage after esophagectomy.Langenbeck's archives of surgery · 2016Article
- [Salvage surgery in esophageal cancer : Feasibility in patients after definitive radiochemotherapy (> 50 Gy)].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Article
- Treatment outcomes of neoadjuvant concurrent chemoradiotherapy followed by esophagectomy for patients with esophageal cancer.Radiation oncology journal · 2015Article
- Surgical strategies for esophageal cancer associated with head and neck cancer.Surgery today · 2014Review
- Risk factors for pulmonary complications after esophagectomy for esophageal cancer.Surgery today · 2014Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to clarify the effect of preoperative chemoradiotherapy (CRT) for esophageal cancer on the postoperative course, and to determine the clinical significance of salvage esophagectomy after definitive CRT.
methodsBased on their preoperative treatment, 477 patients with esophageal cancer were classified into three groups: 253 patients who received surgery alone (Group I), 197 who received planned CRT (30-45 Gy, Group II), and 27 who received a salvage esophagectomy (radiation ≥60 Gy, Group III).
resultsPostoperative complications developed in 25, 40, and 59% of the patients in Groups I, II, and III, respectively, with pulmonary complications developing in 10, 15, and 30%, and anastomotic leakage developing in 13, 23, and 37%, respectively. Mortality rates were 2.4, 2.0, and 7.4%, respectively. Multivariate analysis revealed preoperative therapy to be an independent factor associated with postoperative risks: the odds ratios (ORs) of Groups II and III compared to Group I were 1.8 and 4.0 for pulmonary complications, while they were 1.9 and 2.8, respectively, for anastomotic leakage. No critical complications developed in the 14 patients who received salvage surgery performed with strict surgical indications after 2005. The survival of Group III was not significantly different from that of Groups I and II. Most patients who received an R1/R2 resection after definitive CRT died within 2 years after salvage surgery.
conclusionsPreoperative CRT is associated with postoperative complications especially in patients with R2 resection, while long-term survival can be achieved after R0 resections. Salvage surgery should be considered for carefully selected patients in whom R0 resection can be achieved.
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