ArticleClinical oral investigations2012
Bisphosphonate-associated osteonecrosis of the mandible: reliable soft tissue reconstruction using a local myofascial flap.
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Calcium Phosphate Bone Substitutes in the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Review.Journal of functional biomaterials · 2026Review
- Bisphosphonate and medication induced necrosis of jaws.Bioinformation · 2025Article
- Osteonecrosis of the Jaw.Dentistry journal · 2023Review
- Review
- Oral Surgical Management of Bone and Soft Tissues in MRONJ Treatment: A Decisional Tree.Life (Basel, Switzerland) · 2020Article
- Submental Perforator Flap for Soft-Tissue Reconstruction in Bisphosphonate-Related Osteonecrosis of the Jaws.Craniomaxillofacial trauma & reconstruction · 2017Article
- Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells.Odontology · 2017Article
- Primary wound closure after tooth extraction for prevention of medication-related osteonecrosis of the jaw in patients under denosumab.Clinical oral investigations · 2017Article
- Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review.Oral and maxillofacial surgery · 2016Review
- Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla.Head & face medicine · 2016Article
- Osteonecrosis of the Jaw After Bisphosphonates Treatment in Patients with Multiple Myeloma.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2015Article
- Bisphosphonate-related osteonecrosis of the jaw: specificities.Oncology reviews · 2014Review
- Bisphosphonate associated osteonecrosis of the jaw: an update on pathophysiology, risk factors, and treatment.International journal of dentistry · 2014Review
- Relevance of surgical management of patients affected by bisphosphonate-associated osteonecrosis of the jaws. A prospective clinical and radiological study.Clinical oral investigations · 2014Article
- Incidence of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients taking bisphosphonates for osteoporosis treatment - a grossly underestimated risk?Clinical oral investigations · 2013Article
- Bisphosphonate associated osteomyelitis of the jaw in patients with bony exposure: prevention, a new way of thinking.Journal of applied oral science : revista FOBArticle
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the treatment of bisphosphonate-associated osteonecrosis of the jaw (BP-associated ONJ), poor cure rates are reported. In many cases, repeated osseous exposition and infection may occur. The currently recommended management of affected patients is antibiotic treatment and bony decortication, which is often complicated by soft tissue deficits due to chronic infection. In severe cases osteonecrosis can be managed often only by continuity resections of the mandible. For this purpose, we developed a new surgical procedure, which allows an effective closure of difficult jaw wounds in the lateral mandible. In the last 3 years, 20 patients with BP-associated osteonecrosis of the lower jaw were treated successfully with a modified defect-covering method using a myofascial flap. A mylohyoid muscle flap was detached from mylohyoid line and used to cover the bony defect. During 19 months mean follow-up, 90% of patients were asymptomatic, the oral mucosa was intact, and no exposed bone was observed. In consequence, we are able to demonstrate that a mylohyoid muscle flap provides a reliable wound closure in the lower jaw in patients treated with BPs. Although there are still no consensual therapy guidelines for patients affected by BP-associated ONJ, the results of the presented study provide evidence for an effective surgical therapy with long-term success. Covering compromised bone with well-vascularized tissue, a muscle flap, increased healing chances by enabling and supporting the necessary nutrition and defense against opportunistic infections. This therapy concept showed a good clinical outcome.
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