Evidence map›Paper›PMID 21818544›Full record

ReviewJournal of mammary gland biology and neoplasia2011

Navigating breast cancer: axon guidance molecules as breast cancer tumor suppressors and oncogenes.

Gwyndolen C Harburg, Lindsay Hinck

Abstract readReview
In one paragraph

Review in Journal of mammary gland biology and neoplasia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  7. Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  19. International journal of molecular sciences · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gwyndolen C HarburgDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
Lindsay Hinck
University of California, Santa Cruz · US

Funding

Molecular Basis of Slits as Tumor Suppressors Controlling CXCR4/SDF1 in BreastR01CA128902 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HINCK, LINDSAY E · 2008 to 2012
$1.6M
NCI NIH HHS CA-128902NCI NIH HHS R01 CA128902
6 · The paper itself

Abstract

Slit, Netrin, Ephrin, and Semaphorin's roles in development have expanded greatly in the past decade from their original characterization as axon guidance molecules (AGMs) to include roles as regulators of tissue morphogenesis and development in diverse organs. In the mammary gland, AGMs are important for maintaining normal cell proliferation and adhesion during development. The frequent dysregulation of AGM expression during tumorigenesis and tumor progression suggests that AGMs also play a crucial role as tumor suppressors and oncogenes in breast cancer. Moreover, these findings suggest that AGMs may be excellent targets for new breast cancer prognostic tests and more effective therapeutic strategies.

Indexed as

Genes, Tumor SuppressorOncogenesAnimalsAxonsBreast NeoplasmsFemaleHumansSemaphorinsSemaphorins

Identifiers

PMID21818544
PMCPMC4083826
OpenAlexW1999393768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.