ArticlePloS one2011
Identification and differential expression of microRNAs during metamorphosis of the Japanese flounder (Paralichthys olivaceus).
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 121 citations in OpenAlex.
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- Distinct expression patterns of seven crucial microRNAs during early embryonic development in medaka (Oryzias latipes).Gene expression patterns : GEP · 2020Article
- Genetic features of Haliotis discus hannai by infection of vibrio and virus.Genes & genomics · 2020Review
- Identification and Characterization of lncRNAs Related to the Muscle Growth and Development of Japanese Flounder (Frontiers in genetics · 2020Article
- Gonad-Specific Transcriptomes Reveal Differential Expression of Gene and miRNA Between Male and Female of the Discus Fish (Frontiers in physiology · 2020Article
- Comparative expression analysis of let-7 microRNAs during ovary development in Megalobrama amblycephala.Fish physiology and biochemistry · 2019Article
- Identification and profiling of growth-related microRNAs in Chinese perch (Siniperca chuatsi).BMC genomics · 2017Article
- Identification of Differentially Expressed Micrornas Associate with Glucose Metabolism in Different Organs of Blunt Snout Bream (Megalobrama amblycephala).International journal of molecular sciences · 2017Article
- Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.International journal of molecular sciences · 2017Article
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- miR-1338-5p Modulates Growth Hormone Secretion and Glucose Utilization by RegulatingFrontiers in physiology · 2017Article
- Identification and Characterization of MicroRNAs in the Liver of Blunt Snout Bream (Megalobrama amblycephala) Infected by Aeromonas hydrophila.International journal of molecular sciences · 2016Article
- Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala).Scientific reports · 2016Article
- In silico genome wide mining of conserved and novel miRNAs in the brain and pineal gland of Danio rerio using small RNA sequencing data.Genomics data · 2016Article
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- A key gene of the small RNA pathway in the flounder, Paralichthys olivaceus: identification and functional characterization of dicer.Fish physiology and biochemistry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs of 20-25 nucleotides that play a key role in diverse biological processes. Japanese flounder undergo dramatic metamorphosis in their early development. The metamorphosis is characterized by morphological transformation from a bilaterally symmetrical to an asymmetrical body shape concomitant with extensive morphological and physiological remodeling of organs. So far, only a few miRNAs have been identified in fish and there are very few reports about the Japanese flounder miRNA. METHODOLOGY/PRINCIPAL
findingsSolexa sequencing technology was used to perform high throughput sequencing of the small RNA library from the metamorphic period of Japanese flounder. Subsequently, aligning these sequencing data with metazoan known miRNAs, we characterized 140 conserved miRNAs and 57 miRNA: miRNA* pairs from the small RNA library. Among these 57 miRNA: miRNA* pairs, twenty flounder miRNA precursors were amplified from genomic DNA. We also demonstrated evolutionary conservation of Japanese flounder miRNAs and miRNA* in the animal evolution process. Using miRNA microarrays, we identified 66 differentially expressed miRNAs at two metamorphic stages (17 and 29 days post hatching) of Japanese flounder. The results show that miRNAs might play a key role in regulating gene expression during Japanese flounder metamorphosis. CONCLUSIONS/SIGNIFICANCE: We identified a large number of miRNAs during flounder metamorphosis, some of which are differentially expressed at two different metamorphic stages. The study provides an opportunity for further understanding of miRNA function in the regulation of flounder metamorphosis and gives us clues for further studies of the mechanisms of metamorphosis in Japanese flounder.
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