ArticlePloS one2011
Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Metabolic Responses to High-Fat Feeding and Chronic Psychological Stress Combination.Endocrinology, diabetes & metabolism · 2024Article
- Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats.Scientific reports · 2022Article
- The antidiabetic and hepatoprotective effects of myricitrin on aged mice with D-galactose.Gastroenterology and hepatology from bed to bench · 2020Article
- Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets.Environmental epigenetics · 2019Article
- The Effect of the Taste Receptor Protein T1R3 on the Development of Islet Tissue of the Murine Pancreas.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2019Article
- Inferring population dynamics from single-cell RNA-sequencing time series data.Nature biotechnology · 2019Article
- Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in theeLife · 2018Article
- 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.Nature communications · 2018Article
- A synopsis of factors regulating beta cell development and beta cell mass.Cellular and molecular life sciences : CMLS · 2016Review
- Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth.Physiological reports · 2016Article
- Article
- Development, growth and maintenance of β-cell mass: models are also part of the story.Molecular aspects of medicine · 2015Review
- Stereological estimation and morphological assessment of the endocrine pancreatic components in relation to sex in hen.Veterinary research forum : an international quarterly journal · 2015Article
- Pancreatic β-cell proliferation in obesity.Advances in nutrition (Bethesda, Md.) · 2014Review
- [Pathogenesis of diabetes mellitus and diabetic complications. Studies on diabetic mouse models].Der Pathologe · 2012Review
- Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.Endocrinology · 2012Article
- Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes.PloS one · 2012Article
- Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest.Journal of transplantation · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to examine postnatal islet and beta-cell expansion in healthy female control mice and its disturbances in diabetic GIPR(dn) transgenic mice, which exhibit an early reduction of beta-cell mass. Pancreata of female control and GIPR(dn) transgenic mice, aged 10, 45, 90 and 180 days were examined, using state-of-the-art quantitative-stereological methods. Total islet and beta-cell volumes, as well as their absolute numbers increased significantly until 90 days in control mice, and remained stable thereafter. The mean islet volumes of controls also increased slightly but significantly between 10 and 45 days of age, and then remained stable until 180 days. The total volume of isolated beta-cells, an indicator of islet neogenesis, and the number of proliferating (BrdU-positive) islet cells were highest in 10-day-old controls and declined significantly between 10 and 45 days. In GIPR(dn) transgenic mice, the numbers of islets and beta-cells were significantly reduced from 10 days of age onwards vs. controls, and no postnatal expansion of total islet and beta-cell volumes occurred due to a reduction in islet neogenesis whereas early islet-cell proliferation and apoptosis were unchanged as compared to control mice. Insulin secretion in response to pharmacological doses of GIP was preserved in GIPR(dn) transgenic mice, and serum insulin to pancreatic insulin content in response to GLP-1 and arginine was significantly higher in GIPR(dn) transgenic mice vs. controls. We could show that the increase in islet number is mainly responsible for expansion of islet and beta-cell mass in healthy control mice. GIPR(dn) transgenic mice show a disturbed expansion of the endocrine pancreas, due to perturbed islet neogenesis.
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