ArticlePloS one2011
Three-dimensional imaging of the mouse neurovasculature with magnetic resonance microscopy.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Protocol for In Vivo Two-Photon FCS to Measure Nanocarrier Number and Flow Velocity in Mouse Cerebral Microvasculature.Bio-protocol · 2026Article
- Large Scale in vivo Acquisition, Segmentation and 3D Reconstruction of Cortical Vasculature usingNeuroinformatics · 2025Article
- Vascular phenotyping of the invasive front in breast cancer using a 3D angiogenesis atlas.Microvascular research · 2023Article
- DNA-AgNC Loaded Liposomes for Measuring Cerebral Blood Flow Using Two-Photon Fluorescence Correlation Spectroscopy.ACS nano · 2023Article
- Radiosynthesis of 20-[Prostaglandins, leukotrienes, and essential fatty acids · 2022Article
- Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain.Nature protocols · 2021Review
- Neural anatomy and optical microscopy (NAOMi) simulation for evaluating calcium imaging methods.Journal of neuroscience methods · 2021Article
- Pharmacological validation of TDO as a target for Parkinson's disease.The FEBS journal · 2021Article
- The influence of tumour vasculature on fluid flow in solid tumours: a mathematical modelling study.Biophysics reports · 2021Article
- The cerebral angiome: High resolution MicroCT imaging of the whole brain cerebrovasculature in female and male mice.NeuroImage · 2019Article
- Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling.Contrast media & molecular imaging · 2019Review
- Vessel radius mapping in an extended model of transverse relaxation.Magma (New York, N.Y.) · 2018Article
- MRI Simulation Study Investigating Effects of Vessel Topology, Diffusion, and Susceptibility on Transverse Relaxation Rates Using a Cylinder Fork Model.Scientific reports · 2017Article
- Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Review
- A novel fluorescent imaging technique for assessment of cerebral vasospasm after experimental subarachnoid hemorrhage.Scientific reports · 2017Article
- The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.NeuroImage · 2016Article
- The "Fingerprint" of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging Approach.IEEE transactions on bio-medical engineering · 2016Article
- Synchrotron Radiation X-Ray Phase-Contrast Tomography Visualizes Microvasculature Changes in Mice Brains after Ischemic Injury.Neural plasticity · 2016Article
- Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.Scientific reports · 2015Article
- Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer's disease.Neurophotonics · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
Knowledge of the three-dimensional (3D) architecture of blood vessels in the brain is crucial because the progression of various neuropathologies ranging from Alzheimer's disease to brain tumors involves anomalous blood vessels. The challenges in obtaining such data from patients, in conjunction with development of mouse models of neuropathology, have made the murine brain indispensable for investigating disease induced neurovascular changes. Here we describe a novel method for "whole brain" 3D mapping of murine neurovasculature using magnetic resonance microscopy (μMRI). This approach preserves the vascular and white matter tract architecture, and can be combined with complementary MRI contrast mechanisms such as diffusion tensor imaging (DTI) to examine the interplay between the vasculature and white matter reorganization that often characterizes neuropathologies. Following validation with micro computed tomography (μCT) and optical microscopy, we demonstrate the utility of this method by: (i) combined 3D imaging of angiogenesis and white matter reorganization in both, invasive and non-invasive brain tumor models; (ii) characterizing the morphological heterogeneity of the vascular phenotype in the murine brain; and (iii) conducting "multi-scale" imaging of brain tumor angiogenesis, wherein we directly compared in vivo MRI blood volume measurements with ex vivo vasculature data.
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