Evidence map›Paper›PMID 21818354›Full record

Trial reportPloS one2011

The effect of repetitive transcranial magnetic stimulation on gamma oscillatory activity in schizophrenia.

Mera S Barr, Faranak Farzan, Tamara Arenovich, Robert Chen, Paul B Fitzgerald, Zafiris J Daskalakis

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03288779 nacompletednot on this mapstarted 2017, after this paper: background citation

Theta Burst Stimulation for Schizophrenia

TypeinterventionalSponsorDuke UniversityRan2017 to 2018Enrolled6ConditionsSchizophrenia, Schizoaffective DisorderArmsTheta Burst Stimulation
NCT03741751 naterminatednot on this mapstarted 2019, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation and Cognitive Training for Treatment of Cognitive Problems in Adults With Schizophrenia: A Pilot Randomized Trial

TypeinterventionalSponsorWashington University School of MedicineRan2019 to 2024Enrolled12ConditionsSchizophrenia Spectrum and Other Psychotic Disorders, Cognitive ImpairmentArmsrTMS, Computerized cognitive training
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mera S BarrSchizophrenia Program, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Faranak Farzan
Tamara Arenovich
Robert Chen
Paul B Fitzgerald
Zafiris J Daskalakis
Centre for Addiction and Mental Health · CAUniversity of Toronto · CAThe Alfred Hospital · AU

Funding

Canadian Institutes of Health Research MOP 62917
6 · The paper itself

Abstract

backgroundGamma (γ) oscillations (30-50 Hz) have been shown to be excessive in patients with schizophrenia (SCZ) during working memory (WM). WM is a cognitive process that involves the online maintenance and manipulation of information that is mediated largely by the dorsolateral prefrontal cortex (DLPFC). Repetitive transcranial magnetic stimulation (rTMS) represents a non-invasive method to stimulate the cortex that has been shown to enhance cognition and γ oscillatory activity during WM. METHODOLOGY AND PRINCIPAL

findingsWe examined the effect of 20 Hz rTMS over the DLPFC on γ oscillatory activity elicited during the N-back task in 24 patients with SCZ compared to 22 healthy subjects. Prior to rTMS, patients with SCZ elicited excessive γ oscillatory activity compared to healthy subjects across WM load. Active rTMS resulted in the reduction of frontal γ oscillatory activity in patients with SCZ, while potentiating activity in healthy subjects in the 3-back, the most difficult condition. Further, these effects on γ oscillatory activity were found to be specific to the frontal brain region and were absent in the parieto-occipital brain region. CONCLUSIONS AND SIGNIFICANCE: We suggest that this opposing effect of rTMS on γ oscillatory activity in patients with SCZ versus healthy subjects may be related to homeostatic plasticity leading to differential effects of rTMS on γ oscillatory activity depending on baseline differences. These findings provide important insights into the neurophysiological mechanisms underlying WM deficits in SCZ and demonstrated that rTMS can modulate γ oscillatory activity that may be a possible avenue for cognitive potentiation in this disorder.

Indexed as

Transcranial Magnetic StimulationAdultAntipsychotic AgentsBehaviorCase-Control StudiesDemographyElectroencephalographyEvoked PotentialsFemaleHumansMaleMemory, Short-TermMiddle AgedNeuropsychological TestsPrefrontal CortexSchizophreniaAntipsychotic Agents

Identifiers

PMID21818354
PMCPMC3144924
OpenAlexW1973377774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.