ArticlePloS one2011
Nucleoporin mediated nuclear positioning and silencing of HMR.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer.Oncogene · 2022Article
- A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization.Molecular cell · 2021Article
- Integrity of a heterochromatic domain ensured by its boundary elements.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans.Epigenetics & chromatin · 2020Article
- Recruitment of an Activated Gene to the Yeast Nuclear Pore Complex Requires Sumoylation.Frontiers in genetics · 2020Article
- tRNA Genes Affect Chromosome Structure and Function via Local Effects.Molecular and cellular biology · 2019Article
- Emerging roles for nucleoporins in reproductive cellular physiologyCanadian journal of physiology and pharmacology · 2019Review
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- RNA Polymerase III Advances: Structural and tRNA Functional Views.Trends in biochemical sciences · 2016Review
- Heterochromatin formation via recruitment of DNA repair proteins.Molecular biology of the cell · 2015Article
- Nuclear pore proteins and the control of genome functions.Genes & development · 2015Review
- Nuclear envelope and genome interactions in cell fate.Frontiers in genetics · 2015Review
- The multifunctional nuclear pore complex: a platform for controlling gene expression.Current opinion in cell biology · 2014Review
- Coordination of tRNA transcription with export at nuclear pore complexes in budding yeast.Genes & development · 2014Article
- Long-range heterochromatin association is mediated by silencing and double-strand DNA break repair proteins.The Journal of cell biology · 2013Article
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- TFIIIC localizes budding yeast ETC sites to the nuclear periphery.Molecular biology of the cell · 2012Article
- Human tRNA genes function as chromatin insulators.The EMBO journal · 2012Article
- Nuclear organization and genome function.Annual review of cell and developmental biology · 2012Review
- TFIIIC bound DNA elements in nuclear organization and insulation.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The organization of chromatin domains in the nucleus is an important factor in gene regulation. In eukaryotic nuclei, transcriptionally silenced chromatin clusters at the nuclear periphery while transcriptionally poised chromatin resides in the nuclear interior. Recent studies suggest that nuclear pore proteins (NUPs) recruit loci to nuclear pores to aid in insulation of genes from silencing and during gene activation. We investigated the role of NUPs at a native yeast insulator and show that while NUPs localize to the native tDNA insulator adjacent to the silenced HMR domain, loss of pore proteins does not compromise insulation. Surprisingly we find that NUPs contribute to silencing at HMR and are able to restore silencing to a silencing-defective HMR allele when tethered to the locus. We show that the perinuclear positioning of heterochromatin is important for the NUP-mediated silencing effect and find that loss of NUPs result in decreased localization of HMR to the nuclear periphery. We also show that loss of telomeric tethering pathways does not eliminate NUP localization to HMR, suggesting that NUPs may mediate an independent pathway for HMR association with the nuclear periphery. We propose that localization of NUPs to the tDNA insulator at HMR helps maintain the intranuclear position of the silent locus, which in turn contributes to the fidelity of silencing at HMR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.