ArticleEye (London, England)2011
Reconsidering the connection between vitamin D levels and age-related macular degeneration.
Article in Eye (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- A systematic review of vitamin D status in southern European countries.European journal of nutrition · 2018Pooled it
- Plasma Vitamin D and Intermediate Age-Related Macular Degeneration: Insights from the Longitudinal ALIENOR Study.Ophthalmology science · 2026Article
- Association of serum 25-hydroxyvitamin D levels with age-related macular degeneration and its clinical correlates: a cross-sectional study.Frontiers in endocrinology · 2025Observational
- Review
- Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases.Nutrients · 2022Review
- Serum 25-hydroxy vitamin D levels in age-related macular degeneration.International journal of retina and vitreous · 2022Article
- Article
- The Possible Link Between Vitamin D Levels and Exudative Age-related Macular Degeneration.Oman medical journal · 2020Article
- Serum 25-Hydroxyvitamin D Concentrations and Incidence of Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study.Investigative ophthalmology & visual science · 2019Article
- Vitamin D and Age-Related Macular Degeneration.Nutrients · 2017Review
- Vitamin D Status and Prevalent Early Age-Related Macular Degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study.The journal of nutrition, health & aging · 2017Article
- Vitamin D and Diabetic Complications: True or False Prophet?Diabetes therapy : research, treatment and education of diabetes and related disorders · 2016Review
- Association between vitamin D status and age-related macular degeneration by genetic risk.JAMA ophthalmology · 2015Article
- Vitamin D: Implications for ocular disease and therapeutic potential.Experimental eye research · 2015Review
- Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.Retina (Philadelphia, Pa.) · 2014Article
- Nature and nurture- genes and environment- predict onset and progression of macular degeneration.Progress in retinal and eye research · 2014Review
- The association between plasma 25-hydroxyvitamin D and subgroups in age-related macular degeneration: a cross-sectional study.PloS one · 2013Article
- Association of vitamin D deficiency and age-related macular degeneration in medicare beneficiaries.Archives of ophthalmology (Chicago, Ill. : 1960) · 2012Article
- Association between age-related macular degeneration and 25(OH) vitamin D levels in the Turkish population.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent evidence has suggested a correlation between reduced vitamin D levels and delayed angiogenesis and reduced inflammatory response, which are known to have a major role in the development and progression of age-related macular degeneration (AMD).
designCross-sectional study.
participantsMembers of the Maccabi Healthcare Services (MHS, one of the four largest Israeli Health Maintenance Organization) aged ≥60 years, whose vitamin D levels were taken as part of routine examinations between 2000 and 2008.
methodsAll data for this study were obtained from MHS databases that include medical information on 1.8 million subscribers.
main outcome measuresSerum 25-OH vitamin D levels.
resultsThe total study population comprised of 1045 members diagnosed as having AMD, and 8124 as non-AMD, for whom there was information on vitamin D levels. The mean±SD level of 25-OH vitamin D was 24.1±9.41 ng/ml (range 0.8-120) for the AMD patients and 24.13±9.50 ng/ml (range 0.0-120) for the controls (P=ns). One-third (33.6%) of the AMD patients and 32.86% of the controls had a 25-OH vitamin D level <16 ng/ml, and the proportions of tests in which the 25-OH vitamin D level was >74 ng/ml were 0.19 and 0.14%, respectively (P=ns).
conclusionsNo association was detected between vitamin D levels and the presence of AMD in this cross-sectional study. These results raise some doubt about an association between reduced vitamin D levels and the prevalence of AMD.
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