ArticleActa pharmacologica Sinica2011
Vasorelaxant and antihypertensive effects of formononetin through endothelium-dependent and -independent mechanisms.
Article in Acta pharmacologica Sinica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Blocking mitochondrial cyclophilin D ameliorates TSH-impaired defensive barrier of artery.Redox biology · 2018Trial
- Cardioprotective effect of hydroalcoholic extract stem bark ofPharmaceutical biology · 2026Article
- Antihypertensive Effects of Benzaldehyde in Rats: Involvement of Endothelium-Independent and Endothelium-Dependent Vasorelaxation via Prostacyclin (PGIPharmaceuticals (Basel, Switzerland) · 2026Article
- Formononetin Alleviates MNNG-Triggered Chronic Atrophic Gastritis: Its Potential Mechanisms.Combinatorial chemistry & high throughput screening · 2026Article
- Role of isoflavones in multiple sclerosis.IBRO neuroscience reports · 2025Review
- Effect of formononetin on progressive pulmonary pathologies: multitarget mechanisms and therapeutic prospects.Frontiers in pharmacology · 2025Review
- Article
- Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress.Frontiers in cell and developmental biology · 2024Article
- Formononetin: A Pathway to Protect Neurons.Frontiers in integrative neuroscience · 2022Review
- The Vascular Effects of Isolated Isoflavones-A Focus on the Determinants of Blood Pressure Regulation.Biology · 2021Review
- Network Pharmacological Study and Molecular Docking Analysis of Qiweitangping in Treating Diabetic Coronary Heart Disease.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Anti-Inflammatory Effects of Formononetin 7-Molecules (Basel, Switzerland) · 2019Article
- Endothelium-independent vasodilator effect of isocorynoxeine in vitro isolated from the hook of Uncaria rhynchophylla (Miquel).Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.European journal of medicinal chemistry · 2017Article
- Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy.Virology journal · 2017Article
- Effects of Huang Qi Decoction on Endothelial Dysfunction Induced by Homocysteine.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance CaEvidence-based complementary and alternative medicine : eCAM · 2016Article
- A Review on Medicinal Properties of Orientin.Advances in pharmacological sciences · 2016Review
- Formononetin inhibits enterovirus 71 replication by regulating COX- 2/PGE₂ expression.Virology journal · 2015Article
- Interaction of Isoflavones and Endophyte-Infected Tall Fescue Seed Extract on Vasoactivity of Bovine Mesenteric Vasculature.Frontiers in nutrition · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the mechanisms underlying the vasorelaxant effect of formononetin, an O-methylated isoflavone, in isolated arteries, and its antihypertensive activity in vivo.
methodsArterial rings of superior mesenteric arteries, renal arteries, cerebral basilar arteries, coronary arteries and abdominal aortas were prepared from SD rats. Isometric tension of the arterial rings was recorded using a myograph system. Arterial pressure was measured using tail-cuff method in spontaneously hypertensive rats.
resultsFormononetin (1-300 μmol/L) elicited relaxation in arteries of the five regions that were pre-contracted by KCl (60 mmol/L), U46619 (1 μmol/L) or phenylephrine (10 μmol/L). The formononetin-induced relaxation was reduced by removal of endothelium or by pretreatment with L-NAME (100 μmol/L). Under conditions of endothelium denudation, formononetin (10, 30, and 100 μmol/L) inhibited the contraction induced by KCl and that induced by CaCl(2) in Ca(2+)-free depolarized medium. In the absence of extracellular Ca(2+), formononetin (10, 30, and 100 μmol/L) depressed the constriction caused by phenylephrine (10 μmol/L), but did not inhibit the tonic contraction in response to the addition of CaCl(2) (2 mmol/L). The contraction caused by caffeine (30 mmol/L) was not inhibited by formononetin (100 μmol/L). Formononetin (10 and 100 μmol/L) reduced the change rate of Ca(2+)-fluorescence intensity in response to KCl (50 mmol/L). In spontaneously hypertensive rats, formononetin (5, 10, and 20 mg/kg) slowly lowered the systolic, diastolic and mean arterial pressure.
conclusionFormononetin causes vasodilatation via two pathways: (1) endothelium-independent pathway, probably due to inhibition of voltage-dependent Ca(2+) channels and intracellular Ca(2+) release; and (2) endothelium-dependent pathway by releasing NO. Both the pathways may contribute to its antihypertensive effect.
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