ArticleThe Journal of trauma2011
Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat.
Article in The Journal of trauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02232347 (Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury : a Randomized, Double-blinded, Microdialysis Study
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial.African health sciences · 2017Trial
- Article
- Effects of a Subanesthetic Ketamine Infusion on Inflammatory and Behavioral Outcomes after Closed Head Injury in Rats.Bioengineering (Basel, Switzerland) · 2023Article
- Effects of an intravenous ketamine infusion on inflammatory cytokine levels in male and female Sprague-Dawley rats.Journal of neuroinflammation · 2022Article
- (R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation.Psychopharmacology · 2021Article
- Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain.Iranian journal of basic medical sciences · 2020Article
- A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity That Is Inhibited by Chronic Exposure to Gabapentinoids.Biomolecules · 2020Article
- Ketamine: A Neglected Therapy for Alzheimer Disease.Frontiers in aging neuroscience · 2019Article
- GSK3β: a plausible mechanism of cognitive and hippocampal changes induced by erythropoietin treatment in mood disorders?Translational psychiatry · 2018Review
- Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.PloS one · 2018Article
- Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches.Current topics in behavioral neurosciences · 2017Review
- Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration.Frontiers in pharmacology · 2017Article
- Repair of Neurological Function in Response to FK506 Through CaN/NFATc1 Pathway Following Traumatic Brain Injury in Rats.Neurochemical research · 2016Article
- Tissue-selective inflammation in the oral cavity of the rat.Inflammopharmacology · 2016Article
- Current Status of Ketamine and Related Therapies for Mood and Anxiety Disorders.Current behavioral neuroscience reports · 2015Article
- Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus.Upsala journal of medical sciences · 2015Article
- Review
- Inflammatory consequences in a rodent model of mild traumatic brain injury.Journal of neurotrauma · 2013Article
- Ketamine exerts antidepressant effects and reduces IL-1β and IL-6 levels in rat prefrontal cortex and hippocampus.Experimental and therapeutic medicine · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEndotoxemia from lipopolysaccharide (LPS) induces systemic cytokine production, whereas traumatic brain injury (TBI) increases intracerebral cytokine production. In anesthetic doses, ketamine has potent anti-inflammatory properties. However, its anti-inflammatory effects at subanesthetic doses and its effects on TBI-induced inflammation have not been fully investigated. We hypothesized that ketamine would attenuate both LPS- and TBI-induced inflammatory responses.
methodsMale rats received intraperitoneal (i.p.) ketamine (70 mg/kg, 7 mg/kg, or 1 mg/kg) or saline 1 hour before LPS (20 mg/kg i.p.) or saline. Five hours after LPS, rats were killed. Serum was collected for cytokine analysis. In other experiments, male rats were given ketamine (7 mg/kg i.p.) or saline 1 hour before induction of TBI with controlled cortical impact (or sham). One hour and 6 hours after injury, brain was extracted for analysis of cerebral edema and cytokine production.
resultsLPS increased the serum concentrations of interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ. Ketamine dose dependently attenuated these changes. TBI caused cerebral edema and increased concentrations of cerebral IL-1α, IL-1β, IL-6, IL-10, and tumor necrosis factor-α. However, ketamine had minimal effect on TBI-induced inflammation.
conclusionsAlthough ketamine did not seem to exert any beneficial effects against TBI in the rat, it did not exacerbate cytokine production or enhance cerebral edema as some studies have suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.