Evidence map›Paper›PMID 21817949›Full record

ArticleThe Pediatric infectious disease journal2012

Outcomes and duration of Pneumocystis jiroveci pneumonia therapy in infants with severe combined immunodeficiency.

Ingrid S Lundgren, Janet A Englund, Lauri M Burroughs, Troy R Torgerson, Suzanne Skoda-Smith

Abstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.Journal of the Pediatric Infectious Diseases Society · 2017
    Review
  5. Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.Journal of immunology (Baltimore, Md. : 1950) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ingrid S LundgrenDivision of Infectious Diseases, Seattle Children's Hospital, Seattle, WA 98105, USA. dringridlundgren@gmail.com
Janet A Englund
Lauri M Burroughs
Troy R Torgerson
Suzanne Skoda-Smith

Funding

UNRELATED AND HLA-MISMATCHED RELATED DONOR TRANSPLANTSP01HL036444 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 1986 to 2010
$25.9M
ACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7M
Nonmyeloablative Allografting for Immunodeficiency & Other Nonmalignant DisordersK23HL085288 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BURROUGHS, LAURI M. · 2007 to 2010
$546k
NHLBI NIH HHS HL36444NHLBI NIH HHS K23 HL085288NHLBI NIH HHS P01 HL036444NICHD NIH HHS T32 HD007233NICHD NIH HHS T32HD007233
6 · The paper itself

Abstract

This retrospective review of patients with severe combined immunodeficiency and Pneumocystis jiroveci pneumonia (PCP) evaluated the relationship between duration of therapy to treat PCP and overall survival. We found that 80% of patients receiving only 21 days of antibiotics survived to 12 months beyond hematopoietic cell transplant, whereas only 25% of patients who required longer treatment for PCP survived to stem cell engraftment.

Indexed as

Hematopoietic Stem Cell TransplantationAnti-Infective AgentsFemaleHumansInfantMalePneumocystis cariniiPneumonia, PneumocystisSevere Combined ImmunodeficiencySurvival AnalysisTime FactorsTreatment OutcomeTrimethoprim, Sulfamethoxazole Drug CombinationAnti-Infective AgentsTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID21817949
PMCPMC3244569

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.