ArticleAmerican journal of respiratory cell and molecular biology2012
S-nitrosoglutathione reductase in human lung cancer.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Supersulfide catalysis for nitric oxide and aldehyde metabolism.Science advances · 2023Article
- Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation.Molecules (Basel, Switzerland) · 2021Review
- S-nitrosothiols signaling in cystic fibrosis airways.Journal of biosciences · 2021Review
- The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors.Antioxidants (Basel, Switzerland) · 2020Review
- S-nitrosylation of the Peroxiredoxin-2 promotes S-nitrosoglutathione-mediated lung cancer cells apoptosis via AMPK-SIRT1 pathway.Cell death & disease · 2019Article
- Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling.Antioxidants & redox signaling · 2019Review
- S-Nitrosoglutathione formation at gastric pH is augmented by ascorbic acid and by the antioxidant vitamin complex, Resiston.Pharmaceutical biology · 2018Article
- Nitric Oxide: The Forgotten Child of Tumor Metabolism.Trends in cancer · 2017Review
- S-Nitrosoglutathione Attenuates Airway Hyperresponsiveness in Murine Bronchopulmonary Dysplasia.Molecular pharmacology · 2016Article
- Augmentation of CFTR maturation by S-nitrosoglutathione reductase.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Detection of S-nitroso compounds by use of midinfrared cavity ring-down spectroscopy.Analytical chemistry · 2015Article
- Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.The European respiratory journal · 2015Article
- S-nitrosylation of Ras in breast cancer.Breast cancer research : BCR · 2012Article
- Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.Breast cancer research : BCR · 2012Article
- Biomarkers in asthma: a real hope to better manage asthma.Clinics in chest medicine · 2012Review
- S-Nitrosylation signaling regulates cellular protein interactions.Biochimica et biophysica acta · 2012Review
- Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice.Proteomics · 2012Article
- Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Glutathione in cerebral microvascular endothelial biology and pathobiology: implications for brain homeostasis.International journal of cell biology · 2012Article
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Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
S-Nitrosoglutathione (GSNO) reductase regulates cell signaling pathways relevant to asthma and protects cells from nitrosative stress. Recent evidence suggests that this enzyme may prevent human hepatocellular carcinoma arising in the setting of chronic hepatitis. We hypothesized that GSNO reductase may also protect the lung against potentially carcinogenic reactions associated with nitrosative stress. We report that wild-type Ras is S-nitrosylated and activated by nitrosative stress and that it is denitrosylated by GSNO reductase. In human lung cancer, the activity and expression of GSNO reductase are decreased. Further, the distribution of the enzyme (including its colocalization with wild-type Ras) is abnormal. We conclude that decreased activity of GSNO reductase could leave the human lung vulnerable to the oncogenic effects of nitrosative stress, as is the case in the liver. This potential should be considered when developing therapies that inhibit pulmonary GSNO reductase to treat asthma and other conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.