ArticleMolecular endocrinology (Baltimore, Md.)2011
Skeletal muscle regeneration in mice is stimulated by local overexpression of V1a-vasopressin receptor.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Arginine-Vasopressin Dynamics in Relation to Food Intake and 8-Week Intranasal Oxytocin Treatment in Adults With Obesity.The Journal of clinical endocrinology and metabolism · 2025Trial
- Increased copeptin may reflect vasopressin-related metabolic changes after bariatric surgery.Obesity (Silver Spring, Md.) · 2025Article
- Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023Review
- A tribute to Professor Sergio Adamo, Full Professor of Histology and Embryology at Sapienza University, Rome.European journal of translational myology · 2022Article
- Editorial: Myokines, Adipokines, Cytokines in Muscle Pathophysiology, Volume II.Frontiers in physiology · 2022Article
- Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration.Scientific reports · 2021Article
- Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation.International journal of molecular sciences · 2020Article
- Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives.Current obesity reports · 2019Review
- Inhibition of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Hampers the Vasopressin-dependent Stimulation of Myogenic Differentiation.International journal of molecular sciences · 2019Article
- COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation.Scientific reports · 2018Article
- HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes.Scientific reports · 2018Article
- Skeletal Muscle: A Significant Novel Neurohypophyseal Hormone-Secreting Organ.Frontiers in physiology · 2018Article
- Evaluation of the effect of a floxed Neo cassette within the dystroglycan (Dag1) gene.BMC research notes · 2017Article
- Article
- FES in Europe and Beyond: Current Translational Research.European journal of translational myology · 2016Article
- Stem Cells and Tissue Niche: Two Faces of the Same Coin of Muscle Regeneration.European journal of translational myology · 2016Article
- Action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Arginine vasopressin inhibits adipogenesis in human adipose-derived stem cells.Molecular and cellular endocrinology · 2015Article
- Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis.European journal of translational myology · 2014Review
- Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons.British journal of pharmacology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle has a remarkable capacity to regenerate after mechanical or pathological injury. We show that the V1a receptor (V1aR) for vasopressin, a potent myogenic-promoting factor that stimulates differentiation and hypertrophy in vitro, is expressed in mouse skeletal muscle and modulated during regeneration after experimental injury. We used gene delivery by electroporation to overexpress the myc-tagged vasopressin V1aR in specific muscles, thus sensitizing them to circulating vasopressin. The correct localization on the surface of the fibers of the recombinant product was demonstrated by confocal immunofluorescence directed against the myc tag. V1aR overexpression dramatically enhanced regeneration. When compared with mock-transfected controls, V1aR overexpressing muscles exhibited significantly accelerated activation of satellite cells and increased expression of differentiation markers. Downstream of V1aR activation, calcineurin was strongly up-regulated and stimulated the expression of IL-4, a potent mediator of myogenic cell fusion. The central role of calcineurin in mediating V1aR-dependent myogenesis was also demonstrated by using its specific inhibitor, cyclosporine A. This study identifies skeletal muscle as a physiological target of hormones of the vasopressin family and reveals a novel in vivo role for vasopressin-dependent pathways. These findings unveil several steps, along a complex signaling pathway, that may be exploited as potential targets for the therapy of diseases characterized by altered muscle homeostasis and regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.