ArticleMolecular endocrinology (Baltimore, Md.)2011
A TSH-CREB1-microRNA loop is required for thyroid cell growth.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Circular RNA circRUNX1 promotes papillary thyroid cancer progression and metastasis by sponging MiR-296-3p and regulating DDHD2 expression.Cell death & disease · 2021Article
- Serum TSH levels are associated with postoperative recurrence and lymph node metastasis of papillary thyroid carcinoma.American journal of translational research · 2021Article
- Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient.International journal of endocrinology · 2018Article
- The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.Frontiers in neuroscience · 2016Article
- Circulating miRNAs as biomarkers for endocrine disorders.Journal of endocrinological investigation · 2016Review
- miR-130b-3p Upregulation Contributes to the Development of Thyroid Adenomas Targeting CCDC6 Gene.European thyroid journal · 2015Article
- microRNA-339-5p modulates Na+/I- symporter-mediated radioiodide uptake.Endocrine-related cancer · 2015Article
- MicroRNA in teleost fish.Genome biology and evolution · 2014Review
- Deregulation of microRNA expression in thyroid neoplasias.Nature reviews. Endocrinology · 2014Review
- MiRNA expression may account for chronic but not for acute regulation of mRNA expression in human thyroid tumor models.PloS one · 2014Article
- Article
- Minireview: miRomics in endocrinology: a novel approach for modeling endocrine diseases.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Article
- Developmental effects of tobacco smoke exposure during human embryonic stem cell differentiation are mediated through the transforming growth factor-β superfamily member, Nodal.Differentiation; research in biological diversity · 2012Article
- Identification of microRNAs that mediate thyroid cell growth induced by TSH.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo.PloS one · 2012Article
- microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers.Oncotarget · 2012Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA (miRNA or miR) are an important class of regulators that participate in such biological functions as development, cell proliferation, differentiation, and apoptosis. The aim of this study was to elucidate the role of miRNA in cell proliferation using a unique cell system, namely thyroid cells that require thyrotropin for their growth. Here, we report the identification of a set of five specific miRNA (miR-1, miR-28-A, miR-290-5p, miR-296-3p, and miR-297a), whose down-regulation by thyrotropin is required for thyroid cell growth. In fact, overexpression of these miRNA negatively affects cell growth. We show that three of these miRNA target cAMP-responsive element binding protein (CREB)1, a thyrotropin-activated transcription factor, and that CREB1 binds the regulatory regions of the down-regulated miRNA. Hence, these data indicate that a synergistic loop involving thyrotropin, CREB1, and miRNA is required for thyroid cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.