Evidence map›Paper›PMID 21816787›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2011

True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome.

Lisa M Pastore, Christopher D Williams, Jeffrey Jenkins, James T Patrie

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02491320 (Effect of Acupuncture Pre-treatment Combined With Letrozole on Live Birth in Infertile Women With Polycystic Ovary Syndrome), which is not on this map. Cited by 57 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 12 pooled it
22.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02491320 phase3completednot on this mapstarted 2015, after this paper: background citation

Effect of Acupuncture Pre-treatment Combined With Letrozole on Live Birth in Infertile Women With Polycystic Ovary Syndrome

TypeinterventionalSponsorThe First Affiliated Hospital of Guangzhou Medical UniversityRan2015 to 2019Enrolled384ConditionsPolycystic Ovary SyndromeArmsPre-treatment acupuncture, Letrozole
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 12 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  7. Pharmacological and non-pharmacological strategies for obese women with subfertility.The Cochrane database of systematic reviews · 2021 · on this map
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  9. Acupuncture for polycystic ovarian syndrome.The Cochrane database of systematic reviews · 2019
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  20. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial.American journal of physiology. Endocrinology and metabolism · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lisa M PastoreDepartment of Obstetrics/Gynecology, University of Virginia, Charlottesville, Virginia 22908, USA. lpastore@virginia.edu
Christopher D Williams
Jeffrey Jenkins
James T Patrie
University of Virginia · US

Funding

ZACOPRIDE VS METOCLOPRAMIDE--EFFECT ON LOWER ESOPHAGEAL SPHINCTERM01RR000847 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BRETON, MARC D · 1985 to 2010
$48.1M
Acupuncture/Reproductive Hormones/Ovulation/PolycysticR21AT002520 · NCCIH · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PASTORE, LISA M · 2005 to 2007
$557k
NCCIH NIH HHS R21 AT002520NCRR NIH HHS M01 RR000847NCRR NIH HHS M01RR000847
6 · The paper itself

Abstract

contextAcupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies.

objectiveThe objective of the study was to determine whether true, as compared with sham, acupuncture normalizes pituitary gonadotropin hormones and increases ovulatory frequency in women with PCOS.

designThis was a randomized, double-blind, sham-controlled clinical trial (5 month protocol).

settingThe study was conducted in central Virginia.

participantsEighty-four reproductive-aged women completed the intervention. Eligibility required a PCOS diagnosis and no hormonal intervention 60 d before enrollment.

interventionsIntervention included 12 sessions of true or sham acupuncture (Park sham device) for 8 wk.

main outcome measuresSerum LH and FSH at baseline, after intervention, and 3 months later were measured. Ovulation was measured with weekly urine or blood samples.

resultsBoth arms demonstrated a similar mean ovulation rate over the 5 months (0.37/month among n = 40 true acupuncture and 0.40/month among n = 44 sham participants, P = 0.6), similar LH to FSH ratio improvement (-0.5 and -0.8 true and sham, respectively, P < 0.04 after intervention vs. baseline) and a similar decline in LH over the 5-month protocol (P < 0.05). Neither arm experienced a change in FSH. There were seven pregnancies (no difference by intervention, P = 0.7). Lower fasting insulin and free testosterone were highly correlated with a higher ovulation rate within the true acupuncture group only (P = 0.03), controlling for prestudy menstrual frequency and body mass index.

conclusionWe were unable to discern a difference between the true and sham acupuncture protocols for these women with PCOS, and both groups had a similar improvement in their LH/FSH ratio.

Indexed as

Acupuncture TherapyAdolescentAdultBody Mass IndexCohort StudiesDouble-Blind MethodEducational StatusEthnicityFemaleFollicle Stimulating HormoneHormonesHumansLongitudinal StudiesLuteinizing HormoneMenstruationOvulationFollicle Stimulating HormoneHormonesLuteinizing Hormone

Identifiers

PMID21816787
PMCPMC3200239
OpenAlexW2004219545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.